Non-steroidal anti-inflammatory drug prescriptions from the 6 th month of pregnancy: impact of advice from health authorities

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs. On June 2008 and February 2009, Dear Doctor Letters (DDLs) were sent by the French Health Authorities (AFSSAPS) to remind practitioners of risks with NSAIDs after the fifth month of pregnancy. The aim of this study...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 2019-10, Vol.33 (5), p.581-588
Main Authors: Araujo, Mélanie, Hurault-Delarue, Caroline, Bouilhac, Claire, Petiot, Dominique, Benevent, Justine, Vayssière, Christophe, Vidal, Sabine, Montastruc, Jean-Louis, Damase-Michel, Christine, Lacroix, Isabelle
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Databases, Factual
Drug Prescriptions
Female
Humans
Ibuprofen - therapeutic use
Ketoprofen - therapeutic use
Life Sciences
Niflumic Acid - analogs & derivatives
Niflumic Acid - therapeutic use
Pregnancy
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Summary:Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs. On June 2008 and February 2009, Dear Doctor Letters (DDLs) were sent by the French Health Authorities (AFSSAPS) to remind practitioners of risks with NSAIDs after the fifth month of pregnancy. The aim of this study was to evaluate the impact of these letters on NSAID prescriptions during late pregnancy. EFEMERIS is a French database that registers drugs prescribed and reimbursed during pregnancy and outcomes between 2004 and 2015. We performed a descriptive study and a 'before-and-after' comparison of NSAID prescriptions between 3 June 2006 and 3 June 2008 ('before group'), and between 1 March 2010 and 1 March 2012 ('after group'). We carried out a Cochran Armitage trend test to check whether the rate of women exposed to NSAIDs varies linearly over time. We identified 948 (4.38%) pregnant women in the 'before group' and 678 (2.73%) in the 'after group' receiving at least one NSAID prescription in late pregnancy (P 
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12460