Water-soluble NHC Pd/Ni bimetallic nanoparticles for H/D exchange in aromatic amino-acids

Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023, Vol.59 (8), p.1062-1065
Main Authors: Suárez-Riaño, Oscar, Mencia, Gabriel, Tricard, Simon, Esvan, Jerome, Fazzini, Pier-Francesco, Chaudret, Bruno, Baquero, Edwin A
Format: Article
Language:English
Subjects:
Catalysis
Chemical Sciences
Organic chemistry
Online Access:Get full text
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Summary:Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an enantiospecific fashion without reducing the aromatic ring of phenylalanine and tyrosine thanks to a synergetic Pd–Ni effect.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc06019a