Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels

Transient changes in intracellular calcium ([Ca2+]i) have been shown to punctuate the cell cycle in various types of cells in culture and in early embryos. The [Ca2+]i transients are correlated with cell-cycle events: pronuclear migration, nuclear envelope breakdown, the metaphase-anaphase transitio...

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Bibliographic Details
Published in:Nature (London) 1994-04, Vol.368 (6474), p.875-878
Main Authors: Ciapa, Brigitte, Pesando, Danielle, Wilding, Martin, Whitaker, Michael
Format: Article
Language:English
Subjects:
Animal reproduction
Animals
Biological and medical sciences
Calcium
Calcium - metabolism
Calcium Channels
Calcium Channels - metabolism
Cell Cycle
Cell Cycle - drug effects
Cell cycle, cell proliferation
Cell physiology
Cellular biology
Depsipeptides
Embryos
Emetine
Emetine - pharmacology
Fundamental and applied biological sciences. Psychology
Glycosylphosphatidylinositols
Glycosylphosphatidylinositols - metabolism
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate - metabolism
Inositol 1,4,5-Trisphosphate Receptors
Life Sciences
Mitosis
Molecular and cellular biology
Peptides, Cyclic
Peptides, Cyclic - pharmacology
Receptors, Cytoplasmic and Nuclear
Receptors, Cytoplasmic and Nuclear - metabolism
Sea Urchins
Sea Urchins - embryology
Shellfish
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Summary:Transient changes in intracellular calcium ([Ca2+]i) have been shown to punctuate the cell cycle in various types of cells in culture and in early embryos. The [Ca2+]i transients are correlated with cell-cycle events: pronuclear migration, nuclear envelope breakdown, the metaphase-anaphase transition of mitosis, and cytokinesis. Mitotic events can be induced by injecting calcium and prevented by injecting calcium chelators into the sea urchin embryo. Cell-cycle calcium transients differ from the transients linked to membrane signal transduction pathways: they are generated by an endogenous mechanism, not by plasma membrane receptor complexes, and their trigger is unknown. We report here that the phosphoinositide messenger system oscillates during the early embryonic cell cycle in the sea urchin, leading to cyclic increases in inositol trisphosphate that trigger cell-cycle [Ca2+]i transients and mitosis by calcium release from intracellular stores.
ISSN:0028-0836
1476-4687
DOI:10.1038/368875a0