Cation complexing 2-O-alkylated, 3,6-anhydro-α-cyclodextrins: the side-chain length governs physicochemical properties and practical applications

A series of chain-grafted per-3,6-anhydro-a-cyclodextrins (ACD) were synthesized and their cation complexing properties studied by 1H-NMR spectroscopy. Superficial tension measurements, 1H-NMR spectroscopy and phase diagrams showed that the properties of ACD were closely related to LogP, which also...

Full description

Saved in:
Bibliographic Details
Published in:Journal of drug delivery science and technology 2005, Vol.15 (6), p.419-426
Main Authors: Pailler, J.Y., Gadelle, A., Fauvelle, F., Dabouis, V., Crouzier, D., Debouzy, J.C.
Format: Article
Language:English
Subjects:
Chemical Sciences
Cyclodextrins
Heavy metal decontamination
Membranes
NMR
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of chain-grafted per-3,6-anhydro-a-cyclodextrins (ACD) were synthesized and their cation complexing properties studied by 1H-NMR spectroscopy. Superficial tension measurements, 1H-NMR spectroscopy and phase diagrams showed that the properties of ACD were closely related to LogP, which also controlled their interactions with membranes. As a result, practical applications could be proposed and further perspectives suggested. Hence direct decontamination in liquids may be possible for most amphiphilic derivatives, since these amphiphilic molecules form gels or soaps. The most hydrophobic derivative O36 realizes an insoluble complex that can be used for depollution or cation dosages in liquids.
ISSN:1773-2247
DOI:10.1016/S1773-2247(05)50082-0