Satellite DNA and related diseases

Satellite DNA, also known as tandemly repeated DNA, consists of clusters of repeated sequences and represents a diverse class of highly repetitive elements. Satellite DNA can be divided into several classes according to the size of an individual repeat: microsatellites, minisatellites, midisatellite...

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Bibliographic Details
Published in:Biopolimery i kletka 2014-07, Vol.30 (4), p.249-259
Main Authors: Rich, J., Ogryzko, V. V., Pirozhkova, I. V.
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Deoxyribonucleic acid
Developmental disabilities
DNA
Gene expression
Genomes
Genomics
Human health and pathology
Life Sciences
Microsatellites
Molecular biology
Neurological diseases
Nucleotide sequence
Pediatrics
Pharmaceutical sciences
Quantitative Methods
Satellite DNA
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Summary:Satellite DNA, also known as tandemly repeated DNA, consists of clusters of repeated sequences and represents a diverse class of highly repetitive elements. Satellite DNA can be divided into several classes according to the size of an individual repeat: microsatellites, minisatellites, midisatellites, and macrosatellites. Originally considered as «junk» DNA, satellite DNA has more recently been reconsidered as having various functions. Moreover, due to the repetitive nature of the composing elements, their presence in the genome is associated with high frequency mutations, epigenetic changes and modifications in gene expression patterns, with a potential to lead to human disease. Therefore, the satellite DNA study will be beneficial for developing a treatment of satellite-related diseases, such as FSHD, neurological, developmental disorders and cancers.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.00089E