Homoleptic Organolanthanum-Catalyzed Carbohalogenation

Metal–halogen exchange reactions are fundamental processes in chemistry that transform organic halides into organometallic reagents. However, using these reactions to build intricate structures in a cascade manner, especially in a catalytic mode, has been a challenge. In this study, we introduce a h...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2024-09, Vol.146 (36), p.25361-25370
Main Authors: Yang, Huiyue, Rajeshkumar, Thayalan, Liu, Shanshan, Cong, Hengjiang, Yu, Guipeng, Wang, Lei, Chen, Zhi-Yuan, Wei, Baosheng, Maron, Laurent, Chen, Yi-Hung
Format: Article
Language:English
Subjects:
Chemical Sciences
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Summary:Metal–halogen exchange reactions are fundamental processes in chemistry that transform organic halides into organometallic reagents. However, using these reactions to build intricate structures in a cascade manner, especially in a catalytic mode, has been a challenge. In this study, we introduce a homoleptic organolanthanum catalyst to initiate lanthanum–halogen exchange and intramolecular carbohalogenation. The catalytic pathway can be achieved through metal–halogen exchange and carbometalation, followed by the extraction of halogen atoms from starting materials. Our approach offers a flexible and sustainable way to create a variety of useful compounds, showcasing its potential in chemical synthesis.
ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.4c10445