Sex/gender differences in spontaneous reports to a French Addictovigilance centre

To specify psychoactive substances and related complications observed in spontaneous reports (SRs) in women versus men, we assessed SRs on substance-linked acute toxicity sent to a French Addictovigilance centre. Over the period 2021-2022, 880 SRs were analysed (33.4% concerned women). Severe compli...

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Bibliographic Details
Published in:Archives of women's mental health 2024-07
Main Authors: Peyriére, Héléne, Dampierre, Ange, Vallo, Roselyne, Lestienne, Margot, Eiden, Céline, Donnadieu, Héléne
Format: Article
Language:English
Subjects:
Human health and pathology
Life Sciences
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Summary:To specify psychoactive substances and related complications observed in spontaneous reports (SRs) in women versus men, we assessed SRs on substance-linked acute toxicity sent to a French Addictovigilance centre. Over the period 2021-2022, 880 SRs were analysed (33.4% concerned women). Severe complications concerned more men than women (70.3% versus 59.5%; p = 0.0014). In women, the main implicated substances were psychoactive medications (opioids, benzodiazepines). The most frequently reported complication was suicidal behaviour (14.6% versus 7.8%, p = 0.002). In men, SRs concerned mainly illicit substances (cocaine, amphetamines) or misuse of opioid maintenance therapy or nitrous oxide. The main complications in men were infections (12.97% versus 5.4%, p = 0.0006) and neurological troubles (37.6% versus 23.5%, p 
ISSN:1434-1816
1435-1102
1435-1102
DOI:10.1007/s00737-024-01486-6