Ecological and evolutionary perspectives advance understanding of mycobacterial diseases

Predicting the outbreak of infectious diseases and designing appropriate preventive health actions require interdisciplinary research into the processes that drive exposure to and transmission of disease agents. In the case of mycobacterial diseases, the epidemiological understanding of the scientif...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet. Microbe 2024-11, Vol.5 (11), p.100906, Article 100906
Main Authors: Chevillon, Christine, de Thoisy, Benoît, Rakestraw, Alex W, Fast, Kayla M, Pechal, Jennifer L, Picq, Sophie, Epelboin, Loïc, Le Turnier, Paul, Dogbe, Magdalene, Jordan, Heather R, Sandel, Michael W, Benbow, Mark Eric, Guégan, Jean-François
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Humans
Life Sciences
Mycobacterium - pathogenicity
Mycobacterium Infections - epidemiology
Mycobacterium Infections - microbiology
Mycobacterium Infections - transmission
Santé publique et épidémiologie
Virulence
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Predicting the outbreak of infectious diseases and designing appropriate preventive health actions require interdisciplinary research into the processes that drive exposure to and transmission of disease agents. In the case of mycobacterial diseases, the epidemiological understanding of the scientific community hitherto was based on the clinical studies of infections in vertebrates. To evaluate the information gained by comprehensively accounting for the ecological and evolutionary constraints, we conducted literature searches assessing the role of mycobacteria interactions with non-vertebrate species in the origin of their pathogenicity and variations in disease risk. The reviewed literature challenges the current theory of person-to-person transmission for several mycobacterial infections. Furthermore, the findings suggest that diverse non-vertebrate organisms influence virulence, mediate transmission, and contribute to pathogen abundance in relation to vertebrate exposure. We advocate that an ecological and evolutionary framework provides novel insights to support a more comprehensive understanding of the prevention and management of diseases in vertebrates.
ISSN:2666-5247
2666-5247
DOI:10.1016/S2666-5247(24)00138-1