Impact of the Lung Microbiota on Development and Progression of Lung Cancer

The past several years have provided a more profound understanding of the role of microbial species in the lung. The respiratory tract is a delicate ecosystem of bacteria, fungi, parasites, and viruses. Detecting microbial DNA, pathogen-associated molecular patterns (PAMPs), and metabolites in sputu...

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Bibliographic Details
Published in:Cancers 2024-09, Vol.16 (19), p.3342
Main Authors: Belaid, Amine, Roméo, Barnabé, Rignol, Guylène, Benzaquen, Jonathan, Audoin, Tanguy, Vouret-Craviari, Valérie, Brest, Patrick, Varraso, Raphaëlle, von Bergen, Martin, Hugo Marquette, Charles, Leroy, Sylvie, Mograbi, Baharia, Hofman, Paul
Format: Article
Language:English
Subjects:
Adaptive immunology
Air pollution
Antibiotics
Asthma
Bacteria
Cancer
Carcinogenesis
Chronic illnesses
Chronic obstructive pulmonary disease
Cytokines
Development and progression
Diagnosis
Diet
Dietary intake
Disease management
DNA viruses
Health aspects
Human health and pathology
Immune system
Immunology
Infections
Innate immunity
Life Sciences
Lung cancer
Lung diseases
Microbiology and Parasitology
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Neutrophils
Pathogens
Pollutants
Prevention
Pulmonology and respiratory tract
Respiratory tract
Risk factors
Side effects
Sputum
Taxonomy
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Summary:The past several years have provided a more profound understanding of the role of microbial species in the lung. The respiratory tract is a delicate ecosystem of bacteria, fungi, parasites, and viruses. Detecting microbial DNA, pathogen-associated molecular patterns (PAMPs), and metabolites in sputum is poised to revolutionize the early diagnosis of lung cancer. The longitudinal monitoring of the lung microbiome holds the potential to predict treatment response and side effects, enabling more personalized and effective treatment options. However, most studies into the lung microbiota have been observational and have not adequately considered the impact of dietary intake and air pollutants. This gap makes it challenging to establish a direct causal relationship between environmental exposure, changes in the composition of the microbiota, lung carcinogenesis, and tumor progression. A holistic understanding of the lung microbiota that considers both diet and air pollutants may pave the way to improved prevention and management strategies for lung cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16193342