Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients

• Published in: European journal of nuclear medicine and molecular imaging 2021-06, Vol.48 (6), p.1813-1821
• Main Authors: Djaileb, Loïc, Seiller, Alexandre, Canu, Marjorie, De Leiris, Nicolas, Martin, Alix, Poujol, Julie, Fraguas-Rubio, Alicia, Leenhardt, Julien, Carabelli, Adrien, Calizzano, Alex, De Fondaumière, Marie, Broisat, Alexis, Desvignes, Michel, Vanzetto, Gérald, Ghezzi, Catherine, Fagret, Daniel, Riou, Laurent M., Barone-Rochette, Gilles
• Format: Article
• Language: English
• Subjects: Cardiology; Cardiovascular diseases; Coronary Artery Disease; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnostic imaging; Discrimination; EKG; Entropy; Exercise Test; Heart; Humans; Imaging; Ischemia; Life Sciences; Medical prognosis; Medicine; Medicine & Public Health; Myocardial infarction; Myocardial ischemia; Myocardial Perfusion Imaging; Nuclear Medicine; Oncology; Original Article; Orthopedics; Perfusion; Prognosis; Radiology; Reclassification; Risk analysis; Risk Assessment; Risk Factors; Single photon emission computed tomography; Tomography, Emission-Computed, Single-Photon; Visual discrimination
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-020-05110-4

Purpose Risk stratification of patients with type 2 diabetes mellitus (T2D) remains suboptimal. We hypothesized that myocardial perfusion entropy (MPE) quantified from SPECT myocardial perfusion images may provide incremental prognostic value in T2D patients independently from myocardial ischemia. Methods T2D patients with very high and high cardiovascular risk were prospectively included ( n  = 166, 65 ± 12 years). Stress perfusion defect was quantified by visual evaluation of SPECT MPI. SPECT MPI was also used for the quantification of rest and stress MPE. The primary end point was major adverse cardiac events (MACEs) defined as cardiac death, myocardial infarction (MI), and myocardial revascularization > 3 months after SPECT. Results Forty-four MACEs were observed during a 4.6-year median follow-up. Significant differences in stress MPE were observed between patients with and without MACEs (4.19 ± 0.46 vs. 3.93 ± 0.40; P  ≤ .01). By Kaplan-Meier analysis, the risk of MACEs was significantly higher in patients with higher stress MPE (log-rank P  ≤ 01). Stress MPE and stress perfusion defect (SSS ≥ 4) were significantly associated with the risk of MACEs (hazard ratio 2.77 and 2.06, respectively, P