Access to phage therapy at Hospices Civils de Lyon in 2022: Implementation of the PHAGEinLYON Clinic programme

• Published in: International journal of antimicrobial agents 2024-12, Vol.64 (6), p.107372, Article 107372
• Main Authors: Ferry, Tristan, Bouar, Myrtille Le, Briot, Thomas, Roussel-Gaillard, Tiphaine, Perpoint, Thomas, Roux, Sandrine, Ader, Florence, Valour, Florent, Kassai, Behrouz, Boussaha, Inesse, Ndiaye, Marietou, Craighero, Fabien, Javaux, Clément, Lustig, Sébastien, Batailler, Cécile, Ferry, Tristan , Le Bouar, Myrtille, Briot, Thomas , Wan, Marie, Conrad, Anne, Becker, Agathe, Triffault-Fillit, Claire, Simon, Marie, Braun, Evelyne, Van der Bogaart, Lorena, Chauvelot, Pierre, Bahuaud, Olivier, Landre, Sophie, Soueges, Sarah, Eberl, Isabelle, Dallosto, Karine, Boulant, Johanna, Marrocco, Nathalie, Schmidt, Axel, Fleury, Andréa, El-Ameen, Ali, Schleef, Arnaud, Miailhes, Jade, Fustier, Anne, Himpens, Paul-Henri, Boussel, Loïc, Buisson, Marielle, Kassai, Berhouz
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Bacteriophage; Compassionate Use Trials; Endocarditis; Female; France; Hospices; Humans; Life Sciences; Lung infection; Male; Middle Aged; Phage therapy; Phage Therapy - methods; Prospective Studies; Prosthetic joint infection; Pseudomonas aeruginosa - virology; Pseudomonas Infections - therapy; Retrospective Studies; Staphylococcal Infections - therapy; Staphylococcus aureus - virology
• ISSN: 0924-8579; 1872-7913; 1872-7913; 0924-8579
• DOI: 10.1016/j.ijantimicag.2024.107372

To describe the PHAGEinLYON Clinic programme, set up in 2022 to improve access to phage therapy in France using pharmaceutical-grade phages. All phage therapy requests received during 2022 were collected prospectively, and reviewed retrospectively to analyse the decision and the patient care pathway (NCT05883995). Of 143 requests for phage therapy, the indication was confirmed at a multidisciplinary team meeting for 57 (40%) patients. Forty-four patients were infected with bacteria that could be targeted easily by phages in France. Finally, 33 patients were treated, including 26 at the study institution, through a compassionate access programme or in a clinical trial. The main indication were complex bone and joint infections, endovascular infection and lung infection. In order to manage these patients, 172 pharmaceutical phage cocktails targeting Staphylococcus aureus and/or Pseudomonas aeruginosa were prepared: 57 for local injection and 99 for intravenous injection. During follow-up, 18 (69%) patients showed a favourable clinical evolution, and six (23%) patients required subsequent phage therapy, either with the same phage with greater exposure, or with a different phage from elsewhere. Implementation of the PHAGEinLYON Clinic programme in 2022 was associated with groundbreaking access to phage therapy in France. [Display omitted]