Temporal link between plasma thyrotropin levels and electroencephalographic activity in man

Plasma thyrotropin (TSH) levels have been previously shown to be associated with the internal sleep structure determined by conventional scoring of sleep stages. This temporal relationship was re-evaluated using spectral analysis of the sleep electroencephalogram (EEG). Eight healthy male subjects u...

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Bibliographic Details
Published in:Neuroscience letters 1995-11, Vol.200 (2), p.97-100
Main Authors: Gronfier, C., Luthringer, R., Follenius, M., Schaltenbrand, N., Macher, J.P., Muzet, A., Brandenberger, G.
Format: Article
Language:English
Subjects:
Adult
Alpha Rhythm
Alpha slow-wave index
Biological and medical sciences
Circadian Rhythm - physiology
Data Interpretation, Statistical
Delta relative power
Double-Blind Method
Electroencephalogram
Electroencephalography
Fundamental and applied biological sciences. Psychology
Humans
Life Sciences
Male
Ritanserin - administration & dosage
Sleep
Sleep - drug effects
Sleep - physiology
Sleep. Vigilance
Spectral analysis
Thyrotropin
Thyrotropin - blood
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Plasma thyrotropin (TSH) levels have been previously shown to be associated with the internal sleep structure determined by conventional scoring of sleep stages. This temporal relationship was re-evaluated using spectral analysis of the sleep electroencephalogram (EEG). Eight healthy male subjects underwent two randomized night studies after having received either placebo or 5 mg ritanserin, a selective 5-HT 2 receptor antagonist known to increase slow-wave sleep. Delta relative power and TSH levels, determined at 10 min intervals, were found to be inversely related with an average cross-correlation coefficient highly significant ( P < 0.0001) in both experimental conditions. Alpha slow-wave index, an estimator of awakenings, and TSH pulses exhibited a significant temporal association in both conditions. These results demonstrate that TSH fluctuations are linked to the sleep EEG activity in man.
ISSN:0304-3940
1872-7972
0304-3940
DOI:10.1016/0304-3940(95)12082-F