SEPSIGN: early identification of sepsis signs in emergency department

Because 20-30% of patients with sepsis deteriorate to critical illness, biomarkers that provide accurate early prognosis may identify which patients need more intensive treatment versus safe early discharge. The objective was to test the performance of sVEGFR2, suPAR and PCT, alone or combined with...

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Published in:Internal and emergency medicine 2024-10
Main Authors: Lafon, Thomas, Cazalis, Marie-Angélique, Hart, Kimberly W, Hennessy, Cassandra, Tazarourte, Karim, Self, Wesley H, Akhavan, Arvin Radfar, Laribi, Saïd, Viglino, Damien, Douplat, Marion, Ginde, Adit A, Tolou, Sophie, Mahler, Simon A, Le Borgne, Pierrick, Claessens, Yann-Erick, Yordanov, Youri, Le Bastard, Quentin, Pancher, Agathe, Ducharme, Jim, Lindsell, Christopher J, Shapiro, Nathan I
Format: Article
Language:English
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Life Sciences
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Summary:Because 20-30% of patients with sepsis deteriorate to critical illness, biomarkers that provide accurate early prognosis may identify which patients need more intensive treatment versus safe early discharge. The objective was to test the performance of sVEGFR2, suPAR and PCT, alone or combined with clinical signs and symptoms, for the prediction of clinical deterioration. This prospective observational study enrolled patients with suspected infection who met SIRS criteria without organ dysfunction (delta SOFA
ISSN:1828-0447
1970-9366
1970-9366
DOI:10.1007/s11739-024-03802-5