Rubber hand illusion modulates the influences of somatosensory and parietal inputs to the motor cortex

• Published in: Journal of neurophysiology 2019-02, Vol.121 (2), p.563-573
• Main Authors: Isayama, Reina, Vesia, Michael, Jegatheeswaran, Gaayathiri, Elahi, Behzad, Gunraj, Carolyn A, Cardinali, Lucilla, Farnè, Alessandro, Chen, Robert
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cognitive science; Emerging diseases; Female; Hand - physiology; Human health and pathology; Humans; Illusions; Life Sciences; Male; Middle Aged; Motor Cortex - physiology; Neurons and Cognition; Neuroscience; Psychology; Psychology and behavior; Sensation; Somatosensory Cortex - physiology
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00345.2018

The rubber hand illusion (RHI) paradigm experimentally produces an illusion of rubber hand ownership and arm shift by simultaneously stroking a rubber hand in view and a participant's visually occluded hand. It involves visual, tactile, and proprioceptive multisensory integration and activates multisensory areas in the brain, including the posterior parietal cortex (PPC). Multisensory inputs are transformed into outputs for motor control in association areas such as PPC. A behavioral study reported decreased motor performance after RHI. However, it remains unclear whether RHI modifies the interactions between sensory and motor systems and between PPC and the primary motor cortex (M1). We used transcranial magnetic stimulation (TMS) and examined the functional connections from the primary somatosensory and association cortices to M1 and from PPC to M1 during RHI. In experiment 1, short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) were measured before and immediately after a synchronous (RHI) or an asynchronous (control) condition. In experiment 2, PPC-M1 interaction was measured using two coils. We found that SAI and LAI were reduced in the synchronous condition compared with baseline, suggesting that RHI decreased somatosensory processing in the primary sensory and the association cortices projecting to M1. We also found that greater inhibitory PPC-M1 interaction was associated with stronger RHI assessed by questionnaire. Our findings suggest that RHI modulates both the early and late stages of processing of tactile afferent, which leads to altered M1 excitability by reducing the gain of somatosensory afferents to resolve conflicts among multisensory inputs. NEW & NOTEWORTHY Perception of one's own body parts involves integrating different sensory information and is important for motor control. We found decreased effects of cutaneous stimulation on motor cortical excitability during rubber hand illusion (RHI), which may reflect decreased gain of tactile input to resolve multisensory conflicts. RHI strength correlated with the degree of inhibitory posterior parietal cortex-motor cortex interaction, indicating that parietal-motor connection is involved in resolving sensory conflicts and body ownership during RHI.