Prevalence and prognostic value of autonomic neuropathy assessed by Sudoscan® in transthyretin wild‐type cardiac amyloidosis

Abstract Aims The prevalence of autonomic neuropathy (AN) is high in patients with hereditary transthyretin amyloidosis but remains unknown in transthyretin wild‐type cardiac amyloidosis (ATTRwt‐CA). This study aimed to determine the prevalence of AN in patients with ATTRwt‐CA using Sudoscan®, a non...

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Published in:ESC Heart Failure 2020-12, Vol.8 (2), p.1656-1665
Main Authors: Kharoubi, Mounira, Roche, Fréderic, Bézard, Mélanie, Hupin, David, Silva, Sidney, Oghina, Silvia, Chalard, Coraline, Zaroui, Amira, Galat, Arnault, Guendouz, Soulef, Canoui-Poitrine, Florence, Hittinger, Luc, Teiger, Emmanuel, Lefaucheur, Jean‐pascal, Damy, Thibaud
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Language:English
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Life Sciences
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Summary:Abstract Aims The prevalence of autonomic neuropathy (AN) is high in patients with hereditary transthyretin amyloidosis but remains unknown in transthyretin wild‐type cardiac amyloidosis (ATTRwt‐CA). This study aimed to determine the prevalence of AN in patients with ATTRwt‐CA using Sudoscan®, a non‐invasive method used to provide evidence of AN in clinical practice and based on measurement of electrochemical skin conductance at the hands and feet (fESC). Methods and results A series of 62 non‐diabetic patients with ATTRwt‐CA was prospectively included over 2 years and compared with healthy elderly subjects, matched by age, gender, and body mass index. The presence of AN was defined as electrochemical skin conductance at the hands
ISSN:2055-5822
DOI:10.1002/ehf2.13131