Reactive oxygen species and aldehyde dehydrogenase 1A as prognosis and theragnostic biomarker in acute myeloid leukaemia patients

Acute myeloid leukaemia (AML) remains a major unmet medical, despite recent progress in targeted molecular therapies. One aspect of leukaemic cell resistance to chemotherapy is the development of clones with increased capacity to respond to cellular stress and the production of reactive oxygen speci...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2024-10, Vol.28 (19), p.e70011-n/a
Main Authors: Venton, G., Colle, J., Tichadou, A., Quessada, J., Baier, C., Labiad, Y., Perez, M., De Lassus, L., Loosveld, M., Arnoux, I., Abbou, N., Ceylan, I., Martin, G., Costello, R.
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adult
Aged
Aged, 80 and over
Aldehyde dehydrogenase
Aldehyde Dehydrogenase - metabolism
Aldehyde Dehydrogenase 1 Family - metabolism
Aldehyde Dehydrogenase, Mitochondrial - genetics
Aldehyde Dehydrogenase, Mitochondrial - metabolism
Aldehydes
Antioxidants
Apoptosis
Biochemistry, Molecular Biology
Biomarkers, Tumor - metabolism
Blood
Cancer
Cancer therapies
Cell proliferation
Chemotherapy
Cloning
Cytotoxicity
Drug dosages
Enzymes
Female
Flow cytometry
Hematology
Homeostasis
Human health and pathology
Humans
Leukemia
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - mortality
Leukemia, Myeloid, Acute - pathology
Leukocytes
Life Sciences
Male
Medical prognosis
Middle Aged
Multivariate analysis
Patients
Prognosis
Reactive oxygen species
Reactive Oxygen Species - metabolism
Retinal Dehydrogenase - metabolism
Stem cells
Young Adult
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Summary:Acute myeloid leukaemia (AML) remains a major unmet medical, despite recent progress in targeted molecular therapies. One aspect of leukaemic cell resistance to chemotherapy is the development of clones with increased capacity to respond to cellular stress and the production of reactive oxygen species (ROS), thanks in particular to a high aldehyde dehydrogenases (ALDH) 1A1/2 activity. At diagnosis, ROS level and ALDH1A1/2 activity in AML patients BM are correlated with the different ELN 2022 prognostic groups and overall survival (OS). A significant lower ALDH1A1/2 activity in BM was observed in the favourable ELN2022 subgroup compared to the intermediate and adverse group (p 
ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.70011