Real-world outcomes of lobectomy, segmentectomy and wedge resection for the treatment of stage c-IA lung carcinoma

• Published in: European journal of cardio-thoracic surgery 2024-07, Vol.66 (1)
• Main Authors: Thomas, Pascal Alexandre, Seguin-Givelet, Agathe, Pages, Pierre-Benoît, Alifano, Marco, Brouchet, Laurent, Falcoz, Pierre-Emmanuel, Baste, Jean-Marc, Glorion, Matthieu, Belaroussi, Yaniss, Filaire, Marc, Heyndrickx, Maxime, Loundou, Anderson, Fourdrain, Alex, Dahan, Marcel, Boyer, Laurent
• Format: Article
• Language: English
• Subjects: Cancer; Human health and pathology; Life Sciences; Surgery
• ISSN: 1010-7940; 1873-734X; 1873-734X
• DOI: 10.1093/ejcts/ezae251

Abstract OBJECTIVES To determine safety and survival outcomes associated with lobectomy, segmentectomy and wedge resection for early-stage lung cancer by quiring the French population-based registry EPIdemiology in THORacic surgery (EPITHOR). METHODS Retrospective analysis of 19 452 patients with stage c IA lung carcinoma who underwent lobectomy, segmentectomy or wedge resection between 2016 and 2022 with curative-intent. Main outcome measures were 90-day mortality and 5-year overall survival estimates. Proportional hazards regression and propensity score matching were used to adjust outcomes for key patient, tumour and practice environment factors. RESULTS The treatment distribution was 72.2% for lobectomy, 21.5% for segmentectomy and 6.3% for wedge. Unadjusted 90-day mortality rates were 1.6%, 1.2% and 1.1%, respectively (P = 0.10). Unadjusted 5-year overall survival estimates were 80%, 78% and 70%, with significant inter-group survival curves differences (P