Radiopaque iodinated nano-emulsions for preclinical X-ray imaging

The context of the this research is the development of nanoparticulate systems exhibiting long circulation times in the blood pool, loaded with X-ray contrasting compounds, to be used as blood pool contrast agents in computed tomography. This study presents an original, new and simple formulation of...

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Bibliographic Details
Published in:RSC advances 2011-01, Vol.1 (5), p.792-801
Main Authors: Hallouard, François, Anton, Nicolas, Zuber, Guy, Choquet, Philippe, Li, Xiang, Arntz, Youri, Aubertin, Gaëlle, Constantinesco, André, Vandamme, Thierry F.
Format: Article
Language:English
Subjects:
Blood
Chemical Sciences
Contrast agents
Imaging
Nanocomposites
Nanoemulsions
Nanomaterials
Nanostructure
Pools
X-rays
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Summary:The context of the this research is the development of nanoparticulate systems exhibiting long circulation times in the blood pool, loaded with X-ray contrasting compounds, to be used as blood pool contrast agents in computed tomography. This study presents an original, new and simple formulation of radiopaque nano-emulsions composed of iodinated oil, formed by a spontaneous emulsification method. As a result, extremely monodisperse, iodinated nano-droplets were generated, ranging in size from 20 to 190 nm, presenting an iodine concentration of around 85 mg I/mL, and coated with a polyethylene glycol shell which ensured their stealth properties against the immune system in the blood stream. In vivo assays demonstrated a significant contrast effect, along with a long residence in the blood pool. This study highlights novel nano-formulations used as efficient contrast agents for preclinical X-ray imaging applications, along with simple and efficient alternatives for the generation of iodinated nano-emulsions.
ISSN:2046-2069
2046-2069
DOI:10.1039/c1ra00048a