Polyclonal expansion of TCR Vβ 21.3 + CD4 + and CD8 + T cells is a hallmark of multisystem inflammatory syndrome in children

MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 + and CD8 + T cells that poorly respond to SARS-CoV-2 antigens.

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Bibliographic Details
Published in:Science immunology 2021-05, Vol.6 (59)
Main Authors: Moreews, Marion, Le Gouge, Kenz, Khaldi-Plassart, Samira, Pescarmona, Rémi, Mathieu, Anne-Laure, Malcus, Christophe, Djebali, Sophia, Bellomo, Alicia, Dauwalder, Olivier, Perret, Magali, Villard, Marine, Chopin, Emilie, Rouvet, Isabelle, Vandenesch, Francois, Dupieux, Céline, Pouyau, Robin, Teyssedre, Sonia, Guerder, Margaux, Louazon, Tiphaine, Moulin-Zinsch, Anne, Duperril, Marie, Patural, Hugues, Giovannini-Chami, Lisa, Portefaix, Aurélie, Kassai, Behrouz, Venet, Fabienne, Monneret, Guillaume, Lombard, Christine, Flodrops, Hugues, de Guillebon, Jean-Marie, Bajolle, Fanny, Launay, Valérie, Bastard, Paul, Zhang, Shen-Ying, Dubois, Valérie, Thaunat, Olivier, Richard, Jean-Christophe, Mezidi, Mehdi, Allatif, Omran, Saker, Kahina, Dreux, Marlène, Abel, Laurent, Casanova, Jean-Laurent, Marvel, Jacqueline, Trouillet-Assant, Sophie, Klatzmann, David, Walzer, Thierry, Mariotti-Ferrandiz, Encarnita, Javouhey, Etienne, Belot, Alexandre
Format: Article
Language:English
Subjects:
Human health and pathology
Life Sciences
Pediatrics
Tissues and Organs
Online Access:Get full text
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Description
Summary:MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 + and CD8 + T cells that poorly respond to SARS-CoV-2 antigens.
ISSN:2470-9468
2470-9468
DOI:10.1126/sciimmunol.abh1516