Safety of Fertility Treatments in Women With Systemic Lupus Erythematosus: Data From a Prospective Population-Based Study

• Published in: BJOG : an international journal of obstetrics and gynaecology 2024-12
• Main Authors: Dernoncourt, Amandine, Guettrot-Imbert, Gaëlle, Sentilhes, Loïc, Besse, Marie Charlotte, Molto, Anna, Queyrel-Moranne, Viviane, Besnerais, Maelle Le, Lazaro, Estibaliz, Tieulié, Nathalie, Richez, Christophe, Hachulla, Eric, Sarrot-Reynauld, Françoise, Leroux, Gaëlle, Orquevaux, Pauline, London, Jonathan, Sailler, Laurent, Souchaud-Debouverie, Odile, Smets, Perrine, Godeau, Bertrand, Pannier, Emmanuelle, Murarasu, Anne, Berezne, Alice, Goulenok, Tiphaine, Morel, Nathalie, Mouthon, Luc, Duhaut, Pierre, Guern, Véronique Le, Costedoat-Chalumeau, Nathalie
• Format: Article
• Language: English
• Subjects: Gynecology and obstetrics; Human health and pathology; Life Sciences; Santé publique et épidémiologie
• ISSN: 1470-0328; 1471-0528; 1471-0528
• DOI: 10.1111/1471-0528.18050

To assess safety of fertility treatments in women with systemic lupus erythematosus (SLE). Data from the multicentre French observational GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) study (2014-ongoing). Seventy-six centres in France. All pregnancies in women with SLE enrolled in the GR2 study, conceived before 1 August 2022, with available end-of-pregnancy data and known conception type, were included; that is, 577 spontaneous and 53 assisted pregnancies. A comparative analysis of spontaneous and assisted pregnancies was conducted. Logistic regression was used to determine if fertility treatments were independently associated with live birth prognosis, adjusting for confounders (e.g., maternal age). Kaplan-Meier analysis compared cumulative incidences of disease flares and adverse pregnancy outcomes (APOs), with confounding factors adjusted using a Cox regression model. Live birth, disease flares, and APOs. The mean age was older (35.8 vs. 32.3 years, p