Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius

With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenyla...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2017-10, Vol.80 (10), p.2684-2691
Main Authors: Péresse, Tiphaine, Jézéquel, Gwenaëlle, Allard, Pierre-Marie, Pham, Van-Cuong, Huong, Doan T. M, Blanchard, Florent, Bignon, Jérôme, Lévaique, Hélène, Wolfender, Jean-Luc, Litaudon, Marc, Roussi, Fanny
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Chemical Sciences
Drug Screening Assays, Antitumor
Euphorbiaceae - chemistry
Flavonoids - chemistry
Fruit - chemistry
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves - chemistry
Prenylation
Stilbenes - chemistry
Stilbenes - isolation & purification
Stilbenes - pharmacology
Vietnam
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creator Péresse, Tiphaine
Jézéquel, Gwenaëlle
Allard, Pierre-Marie
Pham, Van-Cuong
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Bignon, Jérôme
Lévaique, Hélène
Wolfender, Jean-Luc
Litaudon, Marc
Roussi, Fanny
description With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K–Q (7–13), were isolated, along with vedelianin (1), schwenfurthins E–G (2–4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1–13 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines.
doi_str_mv 10.1021/acs.jnatprod.7b00409
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subjects Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Chemical Sciences
Drug Screening Assays, Antitumor
Euphorbiaceae - chemistry
Flavonoids - chemistry
Fruit - chemistry
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves - chemistry
Prenylation
Stilbenes - chemistry
Stilbenes - isolation & purification
Stilbenes - pharmacology
Vietnam
title Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius
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