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New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract
Bioassay-guided fractionation of a chloroformic extract obtained from Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening mic...
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| Published in: | Food and chemical toxicology 2010-02, Vol.48 (2), p.553-557 |
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| container_issue | 2 |
| container_start_page | 553 |
| container_title | Food and chemical toxicology |
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| creator | Meot-Duros, Laetitia Cérantola, Stéphane Talarmin, Hélène Le Meur, Christophe Le Floch, Gaëtan Magné, Christian |
| description | Bioassay-guided fractionation of a chloroformic extract obtained from
Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of
Micrococcus luteus and
Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50
μg
ml
−1. Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC
50 value of 20
μM after 48
h of exposition. These results suggest that
Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds. |
| doi_str_mv | 10.1016/j.fct.2009.11.031 |
| format | article |
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Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of
Micrococcus luteus and
Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50
μg
ml
−1. Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC
50 value of 20
μM after 48
h of exposition. These results suggest that
Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2009.11.031</identifier><identifier>PMID: 19922760</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibacterial ; antibacterial properties ; antibiotics ; Apiaceae ; Apiaceae - chemistry ; Bacillus cereus ; Bacillus cereus - drug effects ; Bacillus cereus - growth & development ; bioactive properties ; Biological and medical sciences ; biopesticides ; Cell Line ; Cell Survival - drug effects ; Chemical Fractionation ; Crithmum ; Crithmum maritimum ; Crithmum maritimum L ; Cytotoxicity ; Diynes - analysis ; Diynes - pharmacology ; Enterocytes - drug effects ; Enterocytes - metabolism ; Enterocytes - pathology ; Falcarindiol ; Fatty Alcohols - analysis ; Fatty Alcohols - pharmacology ; food preservatives ; Formazans - metabolism ; General pharmacology ; halophytes ; Intestine, Small ; leaves ; Magnetic Resonance Spectroscopy ; Medical sciences ; medicinal plants ; Microbial Sensitivity Tests ; Micrococcus luteus ; Micrococcus luteus - drug effects ; Micrococcus luteus - growth & development ; minimum inhibitory concentration ; new products ; nuclear magnetic resonance spectroscopy ; perennials ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; Rats ; structure-activity relationships ; Tetrazolium Salts - metabolism</subject><ispartof>Food and chemical toxicology, 2010-02, Vol.48 (2), p.553-557</ispartof><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-f3cb133fca0a6adb621df6265a0a67b924a230a82397368991cab2e6aa818f03</citedby><cites>FETCH-LOGICAL-c541t-f3cb133fca0a6adb621df6265a0a67b924a230a82397368991cab2e6aa818f03</cites><orcidid>0000-0001-6253-7119 ; 0000-0001-7413-8852</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22427347$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19922760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://shs.hal.science/halshs-00651464$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Meot-Duros, Laetitia</creatorcontrib><creatorcontrib>Cérantola, Stéphane</creatorcontrib><creatorcontrib>Talarmin, Hélène</creatorcontrib><creatorcontrib>Le Meur, Christophe</creatorcontrib><creatorcontrib>Le Floch, Gaëtan</creatorcontrib><creatorcontrib>Magné, Christian</creatorcontrib><title>New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Bioassay-guided fractionation of a chloroformic extract obtained from
Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of
Micrococcus luteus and
Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50
μg
ml
−1. Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC
50 value of 20
μM after 48
h of exposition. These results suggest that
Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds.</description><subject>Animals</subject><subject>Antibacterial</subject><subject>antibacterial properties</subject><subject>antibiotics</subject><subject>Apiaceae</subject><subject>Apiaceae - chemistry</subject><subject>Bacillus cereus</subject><subject>Bacillus cereus - drug effects</subject><subject>Bacillus cereus - growth & development</subject><subject>bioactive properties</subject><subject>Biological and medical sciences</subject><subject>biopesticides</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Chemical Fractionation</subject><subject>Crithmum</subject><subject>Crithmum maritimum</subject><subject>Crithmum maritimum L</subject><subject>Cytotoxicity</subject><subject>Diynes - analysis</subject><subject>Diynes - pharmacology</subject><subject>Enterocytes - drug effects</subject><subject>Enterocytes - metabolism</subject><subject>Enterocytes - pathology</subject><subject>Falcarindiol</subject><subject>Fatty Alcohols - analysis</subject><subject>Fatty Alcohols - pharmacology</subject><subject>food preservatives</subject><subject>Formazans - metabolism</subject><subject>General pharmacology</subject><subject>halophytes</subject><subject>Intestine, Small</subject><subject>leaves</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Microbial Sensitivity Tests</subject><subject>Micrococcus luteus</subject><subject>Micrococcus luteus - drug effects</subject><subject>Micrococcus luteus - growth & development</subject><subject>minimum inhibitory concentration</subject><subject>new products</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>perennials</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Rats</subject><subject>structure-activity relationships</subject><subject>Tetrazolium Salts - metabolism</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkcGO0zAQhiMEYsvCA3ABXxAXEjx24iTitKqARargwHK2Jo5NXSXxYrtl9-2ZqtVyg5M9429m_vFfFC-BV8BBvd9VzuRKcN5XABWX8KhYQdfKUskGHhcrLtquVD00F8WzlHac8xZa9bS4gL4XolV8Vfiv9jfDJfsBTbbR40TRyMx9DjncecMo7Q8-e5tYcMzhZDD6ZfRhYj6FCbMdmV_YOvq8nfczm-k5--NtU7HJomP2Lkfq8rx4QtXJvjifl8XNp4836-ty8-3zl_XVpjRNDbl00gwgpTPIUeE4KAGjU0I1x7gdelGjkBw7IftWqq7vweAgrELsoHNcXhbvTm23OOnb6EnPvQ7o9fXVRlMubZPmXDVQq_oAhL894bcx_NrblPXsk7HThIsN-6TbuqEP5FL8n5SyJydESyScSBNDStG6Bx3A9dE4vdNknD4apwE0GUc1r87d98Nsx78VZ6cIeHMGMBmcXMTF-PTACVHT5Po4_PWJcxg0_ozE_PguOEgOXS1paSI-nAhLLhy8jToZbxdjRx8tyRqD_4fQP6ekvrE</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Meot-Duros, Laetitia</creator><creator>Cérantola, Stéphane</creator><creator>Talarmin, Hélène</creator><creator>Le Meur, Christophe</creator><creator>Le Floch, Gaëtan</creator><creator>Magné, Christian</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6253-7119</orcidid><orcidid>https://orcid.org/0000-0001-7413-8852</orcidid></search><sort><creationdate>20100201</creationdate><title>New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract</title><author>Meot-Duros, Laetitia ; Cérantola, Stéphane ; Talarmin, Hélène ; Le Meur, Christophe ; Le Floch, Gaëtan ; Magné, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-f3cb133fca0a6adb621df6265a0a67b924a230a82397368991cab2e6aa818f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antibacterial</topic><topic>antibacterial properties</topic><topic>antibiotics</topic><topic>Apiaceae</topic><topic>Apiaceae - chemistry</topic><topic>Bacillus cereus</topic><topic>Bacillus cereus - drug effects</topic><topic>Bacillus cereus - growth & development</topic><topic>bioactive properties</topic><topic>Biological and medical sciences</topic><topic>biopesticides</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Chemical Fractionation</topic><topic>Crithmum</topic><topic>Crithmum maritimum</topic><topic>Crithmum maritimum L</topic><topic>Cytotoxicity</topic><topic>Diynes - analysis</topic><topic>Diynes - pharmacology</topic><topic>Enterocytes - drug effects</topic><topic>Enterocytes - metabolism</topic><topic>Enterocytes - pathology</topic><topic>Falcarindiol</topic><topic>Fatty Alcohols - analysis</topic><topic>Fatty Alcohols - pharmacology</topic><topic>food preservatives</topic><topic>Formazans - metabolism</topic><topic>General pharmacology</topic><topic>halophytes</topic><topic>Intestine, Small</topic><topic>leaves</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Microbial Sensitivity Tests</topic><topic>Micrococcus luteus</topic><topic>Micrococcus luteus - drug effects</topic><topic>Micrococcus luteus - growth & development</topic><topic>minimum inhibitory concentration</topic><topic>new products</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>perennials</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Rats</topic><topic>structure-activity relationships</topic><topic>Tetrazolium Salts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meot-Duros, Laetitia</creatorcontrib><creatorcontrib>Cérantola, Stéphane</creatorcontrib><creatorcontrib>Talarmin, Hélène</creatorcontrib><creatorcontrib>Le Meur, Christophe</creatorcontrib><creatorcontrib>Le Floch, Gaëtan</creatorcontrib><creatorcontrib>Magné, Christian</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meot-Duros, Laetitia</au><au>Cérantola, Stéphane</au><au>Talarmin, Hélène</au><au>Le Meur, Christophe</au><au>Le Floch, Gaëtan</au><au>Magné, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>48</volume><issue>2</issue><spage>553</spage><epage>557</epage><pages>553-557</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Bioassay-guided fractionation of a chloroformic extract obtained from
Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of
Micrococcus luteus and
Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50
μg
ml
−1. Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC
50 value of 20
μM after 48
h of exposition. These results suggest that
Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>19922760</pmid><doi>10.1016/j.fct.2009.11.031</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-6253-7119</orcidid><orcidid>https://orcid.org/0000-0001-7413-8852</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2010-02, Vol.48 (2), p.553-557 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_halshs_00651464v1 |
| source | Elsevier |
| subjects | Animals Antibacterial antibacterial properties antibiotics Apiaceae Apiaceae - chemistry Bacillus cereus Bacillus cereus - drug effects Bacillus cereus - growth & development bioactive properties Biological and medical sciences biopesticides Cell Line Cell Survival - drug effects Chemical Fractionation Crithmum Crithmum maritimum Crithmum maritimum L Cytotoxicity Diynes - analysis Diynes - pharmacology Enterocytes - drug effects Enterocytes - metabolism Enterocytes - pathology Falcarindiol Fatty Alcohols - analysis Fatty Alcohols - pharmacology food preservatives Formazans - metabolism General pharmacology halophytes Intestine, Small leaves Magnetic Resonance Spectroscopy Medical sciences medicinal plants Microbial Sensitivity Tests Micrococcus luteus Micrococcus luteus - drug effects Micrococcus luteus - growth & development minimum inhibitory concentration new products nuclear magnetic resonance spectroscopy perennials Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plants, Medicinal - chemistry Rats structure-activity relationships Tetrazolium Salts - metabolism |
| title | New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract |
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