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Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons
Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus revealed that glutamate clearance and, as a consequence, glutamate concentration and diffusion in the extracellular space, is associated with the degree of astrocytic coverage of its neurons. Reduction in glutama...
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| Published in: | Science (American Association for the Advancement of Science) 2001-05, Vol.292 (5518), p.923-926 |
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| cites | cdi_FETCH-LOGICAL-c809t-3c04d3af30abd7d853bfb821cdfc9f0346b150bd933c2c8a136c8136c5f748af3 |
| container_end_page | 926 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Stéphane H. R. Oliet Piet, Richard Poulain, Dominique A. |
| description | Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus revealed that glutamate clearance and, as a consequence, glutamate concentration and diffusion in the extracellular space, is associated with the degree of astrocytic coverage of its neurons. Reduction in glutamate clearance, whether induced pharmacologically or associated with a relative decrease of glial coverage in the vicinity of synapses, affected transmitter release through modulation of presynaptic metabotropic glutamate receptors. Astrocytic wrapping of neurons, therefore, contributes to the regulation of synaptic efficacy in the central nervous system. |
| doi_str_mv | 10.1126/science.1059162 |
| format | article |
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R. Oliet</creatorcontrib><creatorcontrib>Piet, Richard</creatorcontrib><creatorcontrib>Poulain, Dominique A.</creatorcontrib><title>Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus revealed that glutamate clearance and, as a consequence, glutamate concentration and diffusion in the extracellular space, is associated with the degree of astrocytic coverage of its neurons. Reduction in glutamate clearance, whether induced pharmacologically or associated with a relative decrease of glial coverage in the vicinity of synapses, affected transmitter release through modulation of presynaptic metabotropic glutamate receptors. 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R. Oliet</au><au>Piet, Richard</au><au>Poulain, Dominique A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2001-05-04</date><risdate>2001</risdate><volume>292</volume><issue>5518</issue><spage>923</spage><epage>926</epage><pages>923-926</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Analysis of excitatory synaptic transmission in the rat hypothalamic supraoptic nucleus revealed that glutamate clearance and, as a consequence, glutamate concentration and diffusion in the extracellular space, is associated with the degree of astrocytic coverage of its neurons. Reduction in glutamate clearance, whether induced pharmacologically or associated with a relative decrease of glial coverage in the vicinity of synapses, affected transmitter release through modulation of presynaptic metabotropic glutamate receptors. Astrocytic wrapping of neurons, therefore, contributes to the regulation of synaptic efficacy in the central nervous system.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>11340204</pmid><doi>10.1126/science.1059162</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-0595-9029</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2001-05, Vol.292 (5518), p.923-926 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_00000059v1 |
| source | American Association for the Advancement of Science; Social Science Premium Collection; Alma/SFX Local Collection; Education Collection |
| subjects | Amino Acid Transport System X-AG Amino acid transport system XAG Aminobutyrates - pharmacology Aminobutyric Acids Anatomy Animals Astrocytes Astrocytes - physiology ATP-Binding Cassette Transporters ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Cells Cellular biology Central nervous system Dicarboxylic Acids Dicarboxylic Acids - pharmacology Electrophysiology Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials Female Fundamental and applied biological sciences. Psychology Glutamate Glutamate receptors Glutamic Aci Glutamic Acid - metabolism Hypothalamic hormones In Vitro Techniques Inhibition Lactation Life Sciences Nervous system Neural transmission Neurons Neurons - physiology Neurons and Cognition Neuroscience Neurotransmitter Uptake Inhibitors - pharmacology Neurotransmitters Pyrrolidines - pharmacology Radio transmitters Rats Rats, Wistar Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, Metabotropic Glutamate - metabolism Supraoptic Nucleus - cytology Supraoptic Nucleus - physiology Synapses - physiology Synaptic transmission Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs |
| title | Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T23%3A10%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Control%20of%20Glutamate%20Clearance%20and%20Synaptic%20Efficacy%20by%20Glial%20Coverage%20of%20Neurons&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=St%C3%A9phane%20H.%20R.%20Oliet&rft.date=2001-05-04&rft.volume=292&rft.issue=5518&rft.spage=923&rft.epage=926&rft.pages=923-926&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1059162&rft_dat=%3Cgale_hal_p%3EA75161741%3C/gale_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c809t-3c04d3af30abd7d853bfb821cdfc9f0346b150bd933c2c8a136c8136c5f748af3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=213576825&rft_id=info:pmid/11340204&rft_galeid=A75161741&rft_jstor_id=3083600&rfr_iscdi=true |