Expression mechanisms of long-term potentiation in the hippocampus

We have taken a number of different experimental approaches to address whether long-term potentiation (LTP) in hippocampal CA1 pyramidal cells is due primarily to presynaptic or postsynaptic modifications. Examination of miniature EPSCs or EPSCs evoked using minimal stimulation indicate that quantal...

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Bibliographic Details
Published in:Journal of physiology, Paris Paris, 1996, Vol.90 (5), p.299-303
Main Authors: Isaac, J.T.R., Oliet, S.H.R., Hjelmstad, G.O., Nicoll, R.A., Malenka, R.C.
Format: Article
Language:English
Subjects:
AMPA receptor
Animals
Evoked Potentials
Hippocampus
Hippocampus - physiology
Life Sciences
Long-Term Potentiation
long-term potentiation (LTP)
miniature synaptic current (mEPSC)
Neurons and Cognition
NMDA receptor
pairing-induced potentiation
probability of transmitter release
Pyramidal Cells
Pyramidal Cells - physiology
silent synapses
Synapses
Synapses - physiology
Synaptic Transmission
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Summary:We have taken a number of different experimental approaches to address whether long-term potentiation (LTP) in hippocampal CA1 pyramidal cells is due primarily to presynaptic or postsynaptic modifications. Examination of miniature EPSCs or EPSCs evoked using minimal stimulation indicate that quantal size increasing during LTP. The conversion of silent to functional synapses may contribute to the LTP-induced changes in mEPSC frequency and failure rate that previously have been attributed to an increase in the probability if transmitter release.
ISSN:0928-4257
1769-7115
DOI:10.1016/S0928-4257(97)87901-6