Cancer mortality after radiotherapy for a skin hemangioma during childhood

A cohort study was performed as part of a European Radiation Protection Program to investigate the carcinogenic effect of treatment with ionizing radiation in early childhood. This paper presents mortality after radiotherapy in this cohort. The cohort comprised 7037 patients under 15 years of age tr...

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Bibliographic Details
Published in:Radiotherapy and oncology 2004-07, Vol.72 (1), p.87-93
Main Authors: Dondon, Marie-Gabrielle, Vathaire, Florent de, Shamsaldin, Akhtar, Doyon, Françoise, Diallo, Ibrahima, Ligot, Laurent, Paoletti, Catherine, Labbé, Martine, Abbas, Moncef, Chavaudra, Jean, Avril, Marie-Françoise, Fragu, Philippe, Eschwège, François
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Childhood
Cohort
Female
Follow-Up Studies
Hemangioma
Hemangioma - radiotherapy
Humans
Infant
Life Sciences
Male
Middle Aged
Mortality
Neoplasms, Radiation-Induced
Neoplasms, Radiation-Induced - mortality
Neurons and Cognition
Radiation
Research Support, Non-U.S. Gov't
Skin Neoplasms
Skin Neoplasms - radiotherapy
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Summary:A cohort study was performed as part of a European Radiation Protection Program to investigate the carcinogenic effect of treatment with ionizing radiation in early childhood. This paper presents mortality after radiotherapy in this cohort. The cohort comprised 7037 patients under 15 years of age treated for a skin hemangioma between 1940 and 1973 at the Institut Gustave-Roussy, among whom 4940 received radiotherapy. The vital status and causes of death were obtained as well as the mortality rates in the general French population. External and internal analyses were performed. Standardized mortality ratio (SMR) and relative risk (RR) variations according to exposure to radiotherapy or not and the type of treatment were studied. During the 1969–1997 follow-up period, 16 cohort patients died of cancer, 14 after radiotherapy. A non-significant excess of cancer-related mortality was observed for irradiated patients as compared to the general population (SMR=1.53; 95% CI=0.86–2.48). Treatment with 226Ra seemed to play a significant role (RR=2.53; 95% CI=0.84–7.07) compared to no radiotherapy. This study suggests an excess risk of cancer-related mortality in patients treated during early childhood with radiotherapy for skin hemangioma, and especially with 226Ra. These patients need to be followed up in the future.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2004.03.011