Hybrid Gadolinium Oxide Nanoparticles:  Multimodal Contrast Agents for in Vivo Imaging

Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxyla...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2007-04, Vol.129 (16), p.5076-5084
Main Authors: Bridot, Jean-Luc, Faure, Anne-Charlotte, Laurent, Sophie, Rivière, Charlotte, Billotey, Claire, Hiba, Bassem, Janier, Marc, Josserand, Véronique, Coll, Jean-Luc, Vander Elst, Luce, Muller, Robert, Roux, Stéphane, Perriat, Pascal, Tillement, Olivier
Format: Article
Language:English
Subjects:
Animals
Cancer
Contrast Media
Contrast Media - chemistry
Contrast Media - pharmacokinetics
Engineering Sciences
Fluorescence
Gadolinium
Gadolinium - blood
Gadolinium - chemistry
Gadolinium - pharmacokinetics
Heterocyclic Compounds
Heterocyclic Compounds - chemistry
Life Sciences
Liver
Liver - metabolism
Lung
Lung - metabolism
Magnetic Resonance Imaging
Materials
Mice
Mice, Nude
Nanoparticles
Nanoparticles - chemistry
Organometallic Compounds
Organometallic Compounds - chemistry
Polyethylene Glycols
Polyethylene Glycols - chemistry
Rats
Siloxanes
Siloxanes - chemistry
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Summary:Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd−DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja068356j