High Expression of Thyroid Hormone Receptors and Mitochondrial Glycerol-3-phosphate Dehydrogenase in the Liver Is Linked to Enhanced Fatty Acid Oxidation in Lou/C, a Rat Strain Resistant to Obesity

Besides its well recognized role in lipid and carbohydrate metabolisms, glycerol is involved in the regulation of cellular energy homeostasis via glycerol-3-phosphate, a key metabolite in the translocation of reducing power across the mitochondrial inner membrane with mitochondrial glycerol-3-phosph...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 2009-02, Vol.284 (7), p.4308-4316
Main Authors: Taleux, Nellie, Guigas, Bruno, Dubouchaud, Hervé, Moreno, Maria, Weitzel, Joachim M., Goglia, Fernando, Favier, Roland, Leverve, Xavier M.
Format: Article
Language:English
Subjects:
Adenosine Diphosphate
Adenosine Diphosphate - metabolism
Adenosine Triphosphate
Adenosine Triphosphate - metabolism
Animals
Fatty Acids
Fatty Acids - metabolism
Gluconeogenesis
Gluconeogenesis - physiology
Glycerol
Glycerol - metabolism
Glycerolphosphate Dehydrogenase
Glycerolphosphate Dehydrogenase - metabolism
Glycerophosphates
Glycerophosphates - metabolism
Hepatocytes
Hepatocytes - metabolism
Male
Mitochondria, Liver
Mitochondria, Liver - metabolism
Monocarboxylic Acid Transporters
NAD
NAD - metabolism
Obesity
Oxidation-Reduction
Rats
Rats, Wistar
Receptors, Thyroid Hormone
Receptors, Thyroid Hormone - metabolism
Species Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Besides its well recognized role in lipid and carbohydrate metabolisms, glycerol is involved in the regulation of cellular energy homeostasis via glycerol-3-phosphate, a key metabolite in the translocation of reducing power across the mitochondrial inner membrane with mitochondrial glycerol-3-phosphate dehydrogenase. Here, we report a high rate of gluconeogenesis from glycerol and fatty acid oxidation in hepatocytes from Lou/C, a peculiar rat strain derived from Wistar, which is resistant to age- and diet-related obesity. This feature, associated with elevated cellular respiration and cytosolic ATP/ADP and NAD+/NADH ratios, was linked to a high expression and activity of mitochondrial glycerol-3-phosphate dehydrogenase. Interestingly, this strain exhibited high expression and protein content of thyroid hormone receptor, whereas circulating thyroid hormone levels were slightly decreased and hepatic thyroid hormone carrier MCT-8 mRNA levels were not modified. We propose that an enhanced liver thyroid hormone receptor in Lou/C may explain its unique resistance to obesity by increasing fatty acid oxidation and lowering liver oxidative phosphorylation stoichiometry at the translocation of reducing power into mitochondria.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M806187200