Splanchnic acid-base status and urea metabolism in uremic rats

Acidosis may alter hepatosplanchnic amino acid metabolism during uremia.26 uremic rats and 30 controls were studied for portal and arterial acid-base balance and urea synthesis during enteral nutrition. Uremic rats exhibited increased (p < 0.05) portal H + (47.20 ± 0.018 vs 43.05 ± 0.49 nmol/I) a...

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Published in:Clinical nutrition (Edinburgh) 1995-04, Vol.14 (2), p.116-122
Main Authors: Cano, N., Leverve, X., Di Costanzo-Dufetel, J., Novaretti, R., Reynier, J.P.
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Biological and medical sciences
Errors of metabolism
Life Sciences
Medical sciences
Metabolic diseases
Proteins and glycoproteins
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Summary:Acidosis may alter hepatosplanchnic amino acid metabolism during uremia.26 uremic rats and 30 controls were studied for portal and arterial acid-base balance and urea synthesis during enteral nutrition. Uremic rats exhibited increased (p < 0.05) portal H + (47.20 ± 0.018 vs 43.05 ± 0.49 nmol/I) and decreased HCO 3 − (19.45 ± 0.69 vs 23.01 ± 0.57 mmol/l) without significant change in arterial H + (45.29 ± 1.13 vs 43.15 ± 0.49) and HCO 3 − (18.41 ± 0.64 vs 19.59 ± 0.49). Porto-arterial difference showed an intestinal HCO 3 − release in controls only (3.53 ± 0.64 mmol/l). Urea synthesis rate was significantly enhanced by enteral nutrition in controls only: 54.33 ± 17.3 vs −11.8 ± 20 μmol/min 100g body mass. Thus, during uremia, portal acidosis was associated with a decrease in enteral nutrition-induced urea synthesis.
ISSN:0261-5614
1532-1983
DOI:10.1016/S0261-5614(95)80031-X