Essential thrombocythemia and pregnancy

Abstract Essential thrombocythaemia (ET) is an acquired myeloproliferative neoplasm, characterised by persistent thrombocytosis and a tendency for either thrombosis or haemorrhage. Among myeloproliferative neoplasms, ET is the most prevalent in young women, which constitute a special group due to th...

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Bibliographic Details
Published in:European Journal of Obstetrics & Gynecology and Reproductive Biology 2011-10, Vol.158 (2), p.141-147
Main Authors: Valera, Marie-Cécile, Parant, Olivier, Vayssiere, Christophe, Arnal, Jean-François, Payrastre, Bernard
Format: Article
Language:English
Subjects:
Biological and medical sciences
Essential thrombocythaemia
Female
Fetal and maternal complications
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Management
Medical sciences
Obstetrics and Gynecology
Pregnancy
Pregnancy Complications, Hematologic
Pregnancy Outcome
Risk Factors
Thrombocythemia, Essential - diagnosis
Thrombocythemia, Essential - genetics
Thrombocythemia, Essential - therapy
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Summary:Abstract Essential thrombocythaemia (ET) is an acquired myeloproliferative neoplasm, characterised by persistent thrombocytosis and a tendency for either thrombosis or haemorrhage. Among myeloproliferative neoplasms, ET is the most prevalent in young women, which constitute a special group due to their childbearing potential. An increased risk of fetal and maternal complications has been demonstrated in patients with ET. The most common pregnancy-related complication is spontaneous abortion during the first trimester. Recurrent abortion, fetal growth restriction, stillbirth and placental abruption are less frequent. Maternal complications are relatively rare and essentially represented by thromboembolic and bleeding events. Here we summarize the literature describing pregnancy and its outcome in patients with ET and discuss some recommendations for the management of pregnancy.
ISSN:0301-2115
1872-7654
2590-1613
DOI:10.1016/j.ejogrb.2011.04.040