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Nitrate-enhanced gated SPECT in patients with primary angioplasty for acute myocardial infarction: evidence of a reversible and nitrate-sensitive impairment of myocardial perfusion
Reperfusion of myocardial infarction (MI) leads to a reversible dysfunction of coronary vessels. We hypothesised that vasodilating drugs such as nitrates might improve sestamibi uptake within viable areas of recently reperfused MI, thereby enhancing prediction of subsequent improvements in perfusion...
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Published in: | European journal of nuclear medicine and molecular imaging 2007-12, Vol.34 (12), p.1981-1990 |
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container_end_page | 1990 |
container_issue | 12 |
container_start_page | 1981 |
container_title | European journal of nuclear medicine and molecular imaging |
container_volume | 34 |
creator | Djaballah, Wassila Muller, Marc A Angioï, Michael Moulin, Frédéric Codreanu, Andrei Mandry, Damien Ethevenot, Gérard Karcher, Gilles Aliot, Etienne Marie, Pierre Y |
description | Reperfusion of myocardial infarction (MI) leads to a reversible dysfunction of coronary vessels. We hypothesised that vasodilating drugs such as nitrates might improve sestamibi uptake within viable areas of recently reperfused MI, thereby enhancing prediction of subsequent improvements in perfusion and contractility. This study was aimed at assessing nitrate-enhanced sestamibi gated SPECT after MI reperfusion.
Twenty-nine patients underwent rest followed by nitrate sestamibi gated SPECT at 9 +/- 3 days after primary angioplasty for acute MI and at follow-up, 4-10 months later. Four MBq/kg of (99m)Tc-sestamibi was injected at rest, and 12 MBq/kg after nitroglycerin spray.
Follow-up improvements were documented for both perfusion (P+) and contractility (C+) in 18% of the 180 initially abnormal segments, in neither perfusion (P-) nor contractility (C-) in 44%, in contractility only (C+P-) in 16% and in perfusion only (C-P+) in 22%. Perfusion improvement was related to lower sestamibi uptake on baseline rest SPECT (P+: 42 +/- 15% vs P-: 50 +/- 15%, p = 0.001) and, moreover, to a higher increase between rest and nitrate uptake (P+: +9.5 +/- 6.5% vs P-: +2.0 +/- 5.9%, p < 0.001). Contractility improvement was related to sestamibi uptake on baseline nitrate SPECT (C+: 58 +/- 15% vs C-: 38 +/- 16%, p < 0.001), a variable enhancing the prediction provided by sestamibi uptake at rest (p < 0.05).
The improvement in perfusion which is documented in the months following MI reperfusion is predicted by initial nitrate enhancement of sestamibi uptake, suggesting a mechanism of reversible vascular injury. In this particular setting, sestamibi uptake is a better predictor of contractility recovery when determined after nitrate administration rather than under conventional resting conditions. |
doi_str_mv | 10.1007/s00259-007-0423-4 |
format | article |
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Twenty-nine patients underwent rest followed by nitrate sestamibi gated SPECT at 9 +/- 3 days after primary angioplasty for acute MI and at follow-up, 4-10 months later. Four MBq/kg of (99m)Tc-sestamibi was injected at rest, and 12 MBq/kg after nitroglycerin spray.
Follow-up improvements were documented for both perfusion (P+) and contractility (C+) in 18% of the 180 initially abnormal segments, in neither perfusion (P-) nor contractility (C-) in 44%, in contractility only (C+P-) in 16% and in perfusion only (C-P+) in 22%. Perfusion improvement was related to lower sestamibi uptake on baseline rest SPECT (P+: 42 +/- 15% vs P-: 50 +/- 15%, p = 0.001) and, moreover, to a higher increase between rest and nitrate uptake (P+: +9.5 +/- 6.5% vs P-: +2.0 +/- 5.9%, p < 0.001). Contractility improvement was related to sestamibi uptake on baseline nitrate SPECT (C+: 58 +/- 15% vs C-: 38 +/- 16%, p < 0.001), a variable enhancing the prediction provided by sestamibi uptake at rest (p < 0.05).
The improvement in perfusion which is documented in the months following MI reperfusion is predicted by initial nitrate enhancement of sestamibi uptake, suggesting a mechanism of reversible vascular injury. In this particular setting, sestamibi uptake is a better predictor of contractility recovery when determined after nitrate administration rather than under conventional resting conditions.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-007-0423-4</identifier><identifier>PMID: 17665196</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Angioplasty, Balloon, Coronary ; Bioinformatics ; Computer Science ; Drug therapy ; Evidence-Based Medicine ; Female ; Heart attacks ; Humans ; Image Enhancement - methods ; Life Sciences ; Male ; Medical imaging ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - therapy ; Nitrates ; Nuclear medicine ; Quantitative Methods ; Radiopharmaceuticals ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon - methods ; Treatment Outcome ; Vasodilator Agents ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - prevention & control</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2007-12, Vol.34 (12), p.1981-1990</ispartof><rights>Springer-Verlag 2007</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-e32b229340b54ef0d6396b3e01721737dc20a64ba73f2d5260343ce21ab79c683</citedby><cites>FETCH-LOGICAL-c363t-e32b229340b54ef0d6396b3e01721737dc20a64ba73f2d5260343ce21ab79c683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17665196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00616490$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Djaballah, Wassila</creatorcontrib><creatorcontrib>Muller, Marc A</creatorcontrib><creatorcontrib>Angioï, Michael</creatorcontrib><creatorcontrib>Moulin, Frédéric</creatorcontrib><creatorcontrib>Codreanu, Andrei</creatorcontrib><creatorcontrib>Mandry, Damien</creatorcontrib><creatorcontrib>Ethevenot, Gérard</creatorcontrib><creatorcontrib>Karcher, Gilles</creatorcontrib><creatorcontrib>Aliot, Etienne</creatorcontrib><creatorcontrib>Marie, Pierre Y</creatorcontrib><title>Nitrate-enhanced gated SPECT in patients with primary angioplasty for acute myocardial infarction: evidence of a reversible and nitrate-sensitive impairment of myocardial perfusion</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Reperfusion of myocardial infarction (MI) leads to a reversible dysfunction of coronary vessels. We hypothesised that vasodilating drugs such as nitrates might improve sestamibi uptake within viable areas of recently reperfused MI, thereby enhancing prediction of subsequent improvements in perfusion and contractility. This study was aimed at assessing nitrate-enhanced sestamibi gated SPECT after MI reperfusion.
Twenty-nine patients underwent rest followed by nitrate sestamibi gated SPECT at 9 +/- 3 days after primary angioplasty for acute MI and at follow-up, 4-10 months later. Four MBq/kg of (99m)Tc-sestamibi was injected at rest, and 12 MBq/kg after nitroglycerin spray.
Follow-up improvements were documented for both perfusion (P+) and contractility (C+) in 18% of the 180 initially abnormal segments, in neither perfusion (P-) nor contractility (C-) in 44%, in contractility only (C+P-) in 16% and in perfusion only (C-P+) in 22%. Perfusion improvement was related to lower sestamibi uptake on baseline rest SPECT (P+: 42 +/- 15% vs P-: 50 +/- 15%, p = 0.001) and, moreover, to a higher increase between rest and nitrate uptake (P+: +9.5 +/- 6.5% vs P-: +2.0 +/- 5.9%, p < 0.001). Contractility improvement was related to sestamibi uptake on baseline nitrate SPECT (C+: 58 +/- 15% vs C-: 38 +/- 16%, p < 0.001), a variable enhancing the prediction provided by sestamibi uptake at rest (p < 0.05).
The improvement in perfusion which is documented in the months following MI reperfusion is predicted by initial nitrate enhancement of sestamibi uptake, suggesting a mechanism of reversible vascular injury. In this particular setting, sestamibi uptake is a better predictor of contractility recovery when determined after nitrate administration rather than under conventional resting conditions.</description><subject>Angioplasty, Balloon, Coronary</subject><subject>Bioinformatics</subject><subject>Computer Science</subject><subject>Drug therapy</subject><subject>Evidence-Based Medicine</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - therapy</subject><subject>Nitrates</subject><subject>Nuclear medicine</subject><subject>Quantitative Methods</subject><subject>Radiopharmaceuticals</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><subject>Treatment Outcome</subject><subject>Vasodilator Agents</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - prevention & control</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpdkV-L1DAUxYso7h_9AL5I8MEnqzdJm0x8W4Z1VxhUcH0OaXq7k6VNa5KOzPfyA5oyZRWfcgK_c-69nKJ4ReE9BZAfIgCrVZllCRXjZfWkOKeCqlLCRj191BLOiosYHwDohm3U8-KMSiFqqsR58fuLS8EkLNHvjbfYkvv8a8n3b9fbO-I8mUxy6FMkv1zakym4wYQjMf7ejVNvYjqSbgzE2DkhGY6jNaF1ps_OzgSb3Og_Ejy4FnM2GTtiSMADhuiaHnNKS_w6P6KPLrkDEjdMxoUhD10M_2ROGLo55sgXxbPO9BFfru9l8ePT9d32ttx9vfm8vdqVlgueSuSsYUzxCpq6wg5awZVoOAKVjEouW8vAiKoxknesrZkAXnGLjJpGKis2_LJ4d8rdm16vp-vROH17tdPORwyDBhBUVAoONONvT_gUxp8zxqQHFy32vfE4zlELtQzgC_jmP_BhnIPPp2hGK1ErkHWG6AmyYYwxYPe4AQW91K9P9etFLvXrKnter8FzM2D717H2zf8AHXmtpw</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Djaballah, Wassila</creator><creator>Muller, Marc A</creator><creator>Angioï, Michael</creator><creator>Moulin, Frédéric</creator><creator>Codreanu, Andrei</creator><creator>Mandry, Damien</creator><creator>Ethevenot, Gérard</creator><creator>Karcher, Gilles</creator><creator>Aliot, Etienne</creator><creator>Marie, Pierre Y</creator><general>Springer Nature B.V</general><general>Springer Verlag (Germany) [1976-....]</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20071201</creationdate><title>Nitrate-enhanced gated SPECT in patients with primary angioplasty for acute myocardial infarction: evidence of a reversible and nitrate-sensitive impairment of myocardial perfusion</title><author>Djaballah, Wassila ; Muller, Marc A ; Angioï, Michael ; Moulin, Frédéric ; Codreanu, Andrei ; Mandry, Damien ; Ethevenot, Gérard ; Karcher, Gilles ; Aliot, Etienne ; Marie, Pierre Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-e32b229340b54ef0d6396b3e01721737dc20a64ba73f2d5260343ce21ab79c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Angioplasty, Balloon, Coronary</topic><topic>Bioinformatics</topic><topic>Computer Science</topic><topic>Drug therapy</topic><topic>Evidence-Based Medicine</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Image Enhancement - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Djaballah, Wassila</au><au>Muller, Marc A</au><au>Angioï, Michael</au><au>Moulin, Frédéric</au><au>Codreanu, Andrei</au><au>Mandry, Damien</au><au>Ethevenot, Gérard</au><au>Karcher, Gilles</au><au>Aliot, Etienne</au><au>Marie, Pierre Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitrate-enhanced gated SPECT in patients with primary angioplasty for acute myocardial infarction: evidence of a reversible and nitrate-sensitive impairment of myocardial perfusion</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>34</volume><issue>12</issue><spage>1981</spage><epage>1990</epage><pages>1981-1990</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Reperfusion of myocardial infarction (MI) leads to a reversible dysfunction of coronary vessels. We hypothesised that vasodilating drugs such as nitrates might improve sestamibi uptake within viable areas of recently reperfused MI, thereby enhancing prediction of subsequent improvements in perfusion and contractility. This study was aimed at assessing nitrate-enhanced sestamibi gated SPECT after MI reperfusion.
Twenty-nine patients underwent rest followed by nitrate sestamibi gated SPECT at 9 +/- 3 days after primary angioplasty for acute MI and at follow-up, 4-10 months later. Four MBq/kg of (99m)Tc-sestamibi was injected at rest, and 12 MBq/kg after nitroglycerin spray.
Follow-up improvements were documented for both perfusion (P+) and contractility (C+) in 18% of the 180 initially abnormal segments, in neither perfusion (P-) nor contractility (C-) in 44%, in contractility only (C+P-) in 16% and in perfusion only (C-P+) in 22%. Perfusion improvement was related to lower sestamibi uptake on baseline rest SPECT (P+: 42 +/- 15% vs P-: 50 +/- 15%, p = 0.001) and, moreover, to a higher increase between rest and nitrate uptake (P+: +9.5 +/- 6.5% vs P-: +2.0 +/- 5.9%, p < 0.001). Contractility improvement was related to sestamibi uptake on baseline nitrate SPECT (C+: 58 +/- 15% vs C-: 38 +/- 16%, p < 0.001), a variable enhancing the prediction provided by sestamibi uptake at rest (p < 0.05).
The improvement in perfusion which is documented in the months following MI reperfusion is predicted by initial nitrate enhancement of sestamibi uptake, suggesting a mechanism of reversible vascular injury. In this particular setting, sestamibi uptake is a better predictor of contractility recovery when determined after nitrate administration rather than under conventional resting conditions.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>17665196</pmid><doi>10.1007/s00259-007-0423-4</doi><tpages>10</tpages></addata></record> |
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subjects | Angioplasty, Balloon, Coronary Bioinformatics Computer Science Drug therapy Evidence-Based Medicine Female Heart attacks Humans Image Enhancement - methods Life Sciences Male Medical imaging Middle Aged Myocardial Infarction - complications Myocardial Infarction - diagnostic imaging Myocardial Infarction - therapy Nitrates Nuclear medicine Quantitative Methods Radiopharmaceuticals Technetium Tc 99m Sestamibi Tomography, Emission-Computed, Single-Photon - methods Treatment Outcome Vasodilator Agents Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - prevention & control |
title | Nitrate-enhanced gated SPECT in patients with primary angioplasty for acute myocardial infarction: evidence of a reversible and nitrate-sensitive impairment of myocardial perfusion |
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