Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia: Genome-wide analysis of bronchopulmonary dysplasia

RATIONALE: Bronchopulmonary dysplasia is the most common chronic respiratory disease in premature infants. Genetic factors might contribute to bronchopulmonary dysplasia susceptibility. OBJECTIVES: To identify genetic variants involved in bronchopulmonary dysplasia through a genome-wide association...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2011-11, Vol.184 (10), p.1164-70
Main Authors: Hadchouel, Alice, Durrmeyer, Xavier, Bouzigon, Emmanuelle, Incitti, Roberto, Huusko, Johanna, Jarreau, Pierre-Henri, Lenclen, Richard, Demenais, Florence, Franco-Montoya, Marie-Laure, Layouni, Ines, Patkai, Juliana, Bourbon, Jacques R., Hallman, Mikko, Danan, Claude, Delacourt, Christophe
Format: Article
Language:English
Subjects:
African Continental Ancestry Group
Animals
Animals, Newborn
Biochemistry, Molecular Biology
Bronchopulmonary Dysplasia
European Continental Ancestry Group
Female
Finland
Gene Expression
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Infant, Newborn
Infant, Premature
Life Sciences
Lung
Male
Polymorphism, Single Nucleotide
Proteoglycans
Rats
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Summary:RATIONALE: Bronchopulmonary dysplasia is the most common chronic respiratory disease in premature infants. Genetic factors might contribute to bronchopulmonary dysplasia susceptibility. OBJECTIVES: To identify genetic variants involved in bronchopulmonary dysplasia through a genome-wide association study. METHODS: We prospectively evaluated 418 premature neonates (gestational age
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201103-0548OC