Carotid and femoral atherosclerotic plaques show different morphology: Patterns of Peripheral Arterial Disease

• Published in: Atherosclerosis 2011-06, Vol.216 (2), p.348-54
• Main Authors: Herisson, Fanny, Heymann, Marie-Françoise, Chétiveaux, Maud, Charrier, Céline, Battaglia, Séverine, Pilet, Paul, Rouillon, Thierry, Krempf, Michel, Lemarchand, Patricia, Heymann, Dominique, Gouëffic, Yann
• Format: Article
• Language: English
• Subjects: Aged; Calcium; Carotid Arteries; Cellular Biology; Cholesterol; Endarterectomy; Female; Femoral Artery; Humans; Immunohistochemistry; Life Sciences; Lipids; Male; Metaplasia; Microscopy, Electron, Scanning; Middle Aged; Plaque, Atherosclerotic; Prospective Studies; Risk Factors
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2011.02.004

OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p