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Carotid and femoral atherosclerotic plaques show different morphology: Patterns of Peripheral Arterial Disease
OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that under...
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| Published in: | Atherosclerosis 2011-06, Vol.216 (2), p.348-54 |
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| container_end_page | 54 |
| container_issue | 2 |
| container_start_page | 348 |
| container_title | Atherosclerosis |
| container_volume | 216 |
| creator | Herisson, Fanny Heymann, Marie-Françoise Chétiveaux, Maud Charrier, Céline Battaglia, Séverine Pilet, Paul Rouillon, Thierry Krempf, Michel Lemarchand, Patricia Heymann, Dominique Gouëffic, Yann |
| description | OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p |
| doi_str_mv | 10.1016/j.atherosclerosis.2011.02.004 |
| format | article |
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We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). Biochemical analyses were consistent with histological data, showing higher calcium and lesser cholesterol concentrations in femoral than in carotid plaques (p<0.01). CONCLUSIONS: Femoral and carotid plaques showed different morphology in comparable groups of patients.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2011.02.004</identifier><identifier>PMID: 21367420</identifier><language>eng</language><publisher>Elsevier</publisher><subject>Aged ; Calcium ; Carotid Arteries ; Cellular Biology ; Cholesterol ; Endarterectomy ; Female ; Femoral Artery ; Humans ; Immunohistochemistry ; Life Sciences ; Lipids ; Male ; Metaplasia ; Microscopy, Electron, Scanning ; Middle Aged ; Plaque, Atherosclerotic ; Prospective Studies ; Risk Factors</subject><ispartof>Atherosclerosis, 2011-06, Vol.216 (2), p.348-54</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5330-2008 ; 0000-0001-7777-0669 ; 0000-0002-5330-2008 ; 0000-0001-7777-0669</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://inserm.hal.science/inserm-00642808$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Herisson, Fanny</creatorcontrib><creatorcontrib>Heymann, Marie-Françoise</creatorcontrib><creatorcontrib>Chétiveaux, Maud</creatorcontrib><creatorcontrib>Charrier, Céline</creatorcontrib><creatorcontrib>Battaglia, Séverine</creatorcontrib><creatorcontrib>Pilet, Paul</creatorcontrib><creatorcontrib>Rouillon, Thierry</creatorcontrib><creatorcontrib>Krempf, Michel</creatorcontrib><creatorcontrib>Lemarchand, Patricia</creatorcontrib><creatorcontrib>Heymann, Dominique</creatorcontrib><creatorcontrib>Gouëffic, Yann</creatorcontrib><title>Carotid and femoral atherosclerotic plaques show different morphology: Patterns of Peripheral Arterial Disease</title><title>Atherosclerosis</title><description>OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). Biochemical analyses were consistent with histological data, showing higher calcium and lesser cholesterol concentrations in femoral than in carotid plaques (p<0.01). CONCLUSIONS: Femoral and carotid plaques showed different morphology in comparable groups of patients.</description><subject>Aged</subject><subject>Calcium</subject><subject>Carotid Arteries</subject><subject>Cellular Biology</subject><subject>Cholesterol</subject><subject>Endarterectomy</subject><subject>Female</subject><subject>Femoral Artery</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Male</subject><subject>Metaplasia</subject><subject>Microscopy, Electron, Scanning</subject><subject>Middle Aged</subject><subject>Plaque, Atherosclerotic</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqVzbFOwzAUheGriqpNC-_ghY2497omcUdUFXVgZLeuGoe4cuJgB1DfniIxsLKcf_mkA3BPKAmp2pwlT51LMZ_Cz_osFRJJVBJRz6AgU-9K0kbfQIGoqNzRIy5hlfMZr6Ims4Clom1Va4UFHPac4uQbwUMjWtfHxEH8fZj8SYyB3z9cFrmLX6LxbeuSGyZxxWMXQ3y73MK85ZDd3W_X8PB8eN0fy46DHZPvOV1sZG-PTy_WD9ml3iJWWhk0n7T9J_8GqXxQOg</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>Herisson, Fanny</creator><creator>Heymann, Marie-Françoise</creator><creator>Chétiveaux, Maud</creator><creator>Charrier, Céline</creator><creator>Battaglia, Séverine</creator><creator>Pilet, Paul</creator><creator>Rouillon, Thierry</creator><creator>Krempf, Michel</creator><creator>Lemarchand, Patricia</creator><creator>Heymann, Dominique</creator><creator>Gouëffic, Yann</creator><general>Elsevier</general><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-5330-2008</orcidid><orcidid>https://orcid.org/0000-0001-7777-0669</orcidid><orcidid>https://orcid.org/0000-0002-5330-2008</orcidid><orcidid>https://orcid.org/0000-0001-7777-0669</orcidid></search><sort><creationdate>201106</creationdate><title>Carotid and femoral atherosclerotic plaques show different morphology</title><author>Herisson, Fanny ; Heymann, Marie-Françoise ; Chétiveaux, Maud ; Charrier, Céline ; Battaglia, Séverine ; Pilet, Paul ; Rouillon, Thierry ; Krempf, Michel ; Lemarchand, Patricia ; Heymann, Dominique ; Gouëffic, Yann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-hal_primary_oai_HAL_inserm_00642808v13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Calcium</topic><topic>Carotid Arteries</topic><topic>Cellular Biology</topic><topic>Cholesterol</topic><topic>Endarterectomy</topic><topic>Female</topic><topic>Femoral Artery</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Male</topic><topic>Metaplasia</topic><topic>Microscopy, Electron, Scanning</topic><topic>Middle Aged</topic><topic>Plaque, Atherosclerotic</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herisson, Fanny</creatorcontrib><creatorcontrib>Heymann, Marie-Françoise</creatorcontrib><creatorcontrib>Chétiveaux, Maud</creatorcontrib><creatorcontrib>Charrier, Céline</creatorcontrib><creatorcontrib>Battaglia, Séverine</creatorcontrib><creatorcontrib>Pilet, Paul</creatorcontrib><creatorcontrib>Rouillon, Thierry</creatorcontrib><creatorcontrib>Krempf, Michel</creatorcontrib><creatorcontrib>Lemarchand, Patricia</creatorcontrib><creatorcontrib>Heymann, Dominique</creatorcontrib><creatorcontrib>Gouëffic, Yann</creatorcontrib><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herisson, Fanny</au><au>Heymann, Marie-Françoise</au><au>Chétiveaux, Maud</au><au>Charrier, Céline</au><au>Battaglia, Séverine</au><au>Pilet, Paul</au><au>Rouillon, Thierry</au><au>Krempf, Michel</au><au>Lemarchand, Patricia</au><au>Heymann, Dominique</au><au>Gouëffic, Yann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carotid and femoral atherosclerotic plaques show different morphology: Patterns of Peripheral Arterial Disease</atitle><jtitle>Atherosclerosis</jtitle><date>2011-06</date><risdate>2011</risdate><volume>216</volume><issue>2</issue><spage>348</spage><epage>54</epage><pages>348-54</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). 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| ispartof | Atherosclerosis, 2011-06, Vol.216 (2), p.348-54 |
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| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Aged Calcium Carotid Arteries Cellular Biology Cholesterol Endarterectomy Female Femoral Artery Humans Immunohistochemistry Life Sciences Lipids Male Metaplasia Microscopy, Electron, Scanning Middle Aged Plaque, Atherosclerotic Prospective Studies Risk Factors |
| title | Carotid and femoral atherosclerotic plaques show different morphology: Patterns of Peripheral Arterial Disease |
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