Herpes zoster: Burden of disease in France

Abstract This work provides estimates of HZ incidence and HZ-related hospitalization and mortality rates in France, where no immunization programme has been implemented. Herpes zoster data was obtained from the Sentinelles surveillance general practitioners (GPs) network, the PMSI Data processing ce...

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Bibliographic Details
Published in:Vaccine 2010-11, Vol.28 (50), p.7933-7938
Main Authors: Gonzalez Chiappe, S, Sarazin, M, Turbelin, C, Lasserre, A, Pelat, C, Bonmarin, I, Chosidow, O, Blanchon, T, Hanslik, T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Child
Child, Preschool
Cost of Illness
Data processing
Female
France
France - epidemiology
Fundamental and applied biological sciences. Psychology
Herpes Zoster
Herpes Zoster - epidemiology
Herpes Zoster - mortality
Hospitalization
Hospitalization - statistics & numerical data
Hospitals
Human viral diseases
Humans
Immunization
Incidence
Infant
Infant, Newborn
Infectious diseases
Life Sciences
Male
Medical sciences
Metabolic disorders
Microbiology
Middle Aged
Mortality
Older people
Santé publique et épidémiologie
Sentinel Surveillance
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Young Adult
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Summary:Abstract This work provides estimates of HZ incidence and HZ-related hospitalization and mortality rates in France, where no immunization programme has been implemented. Herpes zoster data was obtained from the Sentinelles surveillance general practitioners (GPs) network, the PMSI Data processing centre for hospital discharges and from the French National Mortality Database (INSERM CépiDC). The yearly HZ incidence rate averaged 382 cases per 100,000 inhabitants (95% CI 364–405) and exponentially increased with age. The annual rates of hospitalizations and mortality due to HZ varied from 4.14 ± 0.32 to 14.42 ± 0.39 and from 0.11 ± 0.03 to 0.29 ± 0.04 per 100,000 inhabitants, respectively, depending on whether HZ was coded in a ‘primary’ or ‘primary or associated’ diagnosis. One or more factors of immunodepression occurred in 43.4% of hospitalized cases and in 21.6% HZ-related deaths.
ISSN:0264-410X
1873-2518
0264-410X
DOI:10.1016/j.vaccine.2010.09.074