The DTI Challenge: Toward Standardized Evaluation of Diffusion Tensor Imaging Tractography for Neurosurgery

• Published in: Journal of neuroimaging 2015-11, Vol.25 (6), p.875-882
• Main Authors: Pujol, Sonia, Wells, William, Pierpaoli, Carlo, Brun, Caroline, Gee, James, Cheng, Guang, Vemuri, Baba, Commowick, Olivier, Prima, Sylvain, Stamm, Aymeric, Goubran, Maged, Khan, Ali, Peters, Terry, Neher, Peter, Maier-Hein, Klaus H., Shi, Yundi, Tristan-Vega, Antonio, Veni, Gopalkrishna, Whitaker, Ross, Styner, Martin, Westin, Carl-Fredrik, Gouttard, Sylvain, Norton, Isaiah, Chauvin, Laurent, Mamata, Hatsuho, Gerig, Guido, Nabavi, Arya, Golby, Alexandra, Kikinis, Ron
• Format: Article
• Language: English
• Subjects: Algorithms; Brain - diagnostic imaging; Brain - pathology; Brain - surgery; brain gliomas; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Diffusion; Diffusion MRI; diffusion tensor imaging (DTI); Diffusion Tensor Imaging - methods; Diffusion Tensor Imaging - standards; Glioma - diagnostic imaging; Glioma - pathology; Glioma - surgery; Humans; Image Processing, Computer-Assisted - methods; Image Processing, Computer-Assisted - standards; Life Sciences; Neuroimaging; Neurons and Cognition; Neurosurgery; Neurosurgical Procedures - methods; Neurosurgical Procedures - standards; Pyramidal Tracts - diagnostic imaging; Pyramidal Tracts - pathology; Pyramidal Tracts - surgery; Reference Standards; tractography; White Matter - diagnostic imaging; White Matter - pathology; White Matter - surgery
• ISSN: 1051-2284; 1552-6569
• DOI: 10.1111/jon.12283

ABSTRACT BACKGROUND AND PURPOSE Diffusion tensor imaging (DTI) tractography reconstruction of white matter pathways can help guide brain tumor resection. However, DTI tracts are complex mathematical objects and the validity of tractography‐derived information in clinical settings has yet to be fully established. To address this issue, we initiated the DTI Challenge, an international working group of clinicians and scientists whose goal was to provide standardized evaluation of tractography methods for neurosurgery. The purpose of this empirical study was to evaluate different tractography techniques in the first DTI Challenge workshop. METHODS Eight international teams from leading institutions reconstructed the pyramidal tract in four neurosurgical cases presenting with a glioma near the motor cortex. Tractography methods included deterministic, probabilistic, filtered, and global approaches. Standardized evaluation of the tracts consisted in the qualitative review of the pyramidal pathways by a panel of neurosurgeons and DTI experts and the quantitative evaluation of the degree of agreement among methods. RESULTS The evaluation of tractography reconstructions showed a great interalgorithm variability. Although most methods found projections of the pyramidal tract from the medial portion of the motor strip, only a few algorithms could trace the lateral projections from the hand, face, and tongue area. In addition, the structure of disagreement among methods was similar across hemispheres despite the anatomical distortions caused by pathological tissues. CONCLUSIONS The DTI Challenge provides a benchmark for the standardized evaluation of tractography methods on neurosurgical data. This study suggests that there are still limitations to the clinical use of tractography for neurosurgical decision making.