Intestinal Adaptations after Bariatric Surgery: Consequences on Glucose Homeostasis

The gastrointestinal (GI) tract can play a direct role in glucose homeostasis by modulating the digestion and absorption of carbohydrates and by producing the incretin hormones. In recent years, numerous studies have focused on intestinal adaptation following bariatric surgeries. Changes in the numb...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2017-05, Vol.28 (5), p.354-364
Main Authors: Cavin, Jean-Baptiste, Bado, André, Le Gall, Maude
Format: Article
Language:English
Subjects:
Bariatric Surgery - adverse effects
Endocrinology & Metabolism
Food and Nutrition
Gastric Inhibitory Polypeptide - metabolism
Glucagon-Like Peptide 1 - metabolism
Glucose - metabolism
Homeostasis - physiology
Human health and pathology
Humans
Hépatology and Gastroenterology
Intestines - metabolism
Intestines - surgery
Life Sciences
Surgery
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Summary:The gastrointestinal (GI) tract can play a direct role in glucose homeostasis by modulating the digestion and absorption of carbohydrates and by producing the incretin hormones. In recent years, numerous studies have focused on intestinal adaptation following bariatric surgeries. Changes in the number of incretin (glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide) producing cells have been reported, which could result in the modified hormonal response seen after surgery. In addition, the rate of absorption and the intestinal regions exposed to sugars may affect the time course of appearance of glucose in the blood. This review gives new insights into the direct role of the GI tract in the metabolic outcomes of bariatric surgery, in the context of glucose homeostasis.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2017.01.002