Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern

Severity of lithium poisoning depends on the ingested dose, previous treatment duration and renal function. No animal study has investigated neurobehavioral differences in relation to the lithium poisoning pattern observed in humans, while differences in lithium pharmacokinetics have been reported i...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2017-03, Vol.76, p.124-133
Main Authors: Hanak, Anne-Sophie, Chevillard, Lucie, Lebeau, Rodolphe, Risède, Patricia, Laplanche, Jean-Louis, Benturquia, Nadia, Megarbane, Bruno
Format: Article
Language:English
Subjects:
Human health and pathology
Life Sciences
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Summary:Severity of lithium poisoning depends on the ingested dose, previous treatment duration and renal function. No animal study has investigated neurobehavioral differences in relation to the lithium poisoning pattern observed in humans, while differences in lithium pharmacokinetics have been reported in lithium-pretreated rats mimicking chronic poisonings with enhanced brain accumulation in rats with renal failure. Our objectives were: 1)-to investigate lithium-related effects in overdose on locomotor activity, anxiety-like behavior, spatial recognition memory and anhedonia in the rat; 2)-to model the relationships between lithium-induced effects on locomotion and plasma, erythrocyte, cerebrospinal fluid and brain concentrations previously obtained according to the poisoning pattern. Open-field, elevated plus-maze, Y-maze and sucrose consumption tests were used. In acutely lithium-poisoned rats, we observed horizontal (p
ISSN:0278-5846
1878-4216