A single, low dose of a cGMP recombinant BCG vaccine elicits protective T cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice

Highlights • A single dose of 3 × 105 CFUs of rBCG-N-hRSV cGMP elicits T-cell memory against hRSV. • rBCG-N-hRSV cGMP elicits a strong antiviral TH1/TH17 T-cell repertoire. • Vaccination prevents viral pneumonia and CNS-alterations associated with hRSV. • rBCG-N-hRSV cGMP elicits a strong anti-mycob...

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Published in:Vaccine 2017-02, Vol.35 (5), p.757-766
Main Authors: Céspedes, Pablo F, Rey-Jurado, Emma, Espinoza, Janyra A, Rivera, Claudia A, Canedo-Marroquín, Gisela, Bueno, Susan M, Kalergis, Alexis M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigens
Bacillus Calmette et Guerin
BCG Vaccine - administration & dosage
BCG Vaccine - genetics
BCG Vaccine - immunology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - virology
Epidemics
Human health and pathology
Human respiratory syncytial virus
Humans
Immunity, Cellular - drug effects
Immunization
Immunization Schedule
Immunogenicity, Vaccine
Immunology
Infections
Interferon-gamma - biosynthesis
Interferon-gamma - immunology
Interleukin-17 - biosynthesis
Interleukin-17 - immunology
Laboratory animals
Life Sciences
Lung - drug effects
Lung - immunology
Lung - virology
Lungs
Lymphocyte Activation - drug effects
Lymphocytes
Mice
Mice, Inbred BALB C
Neutrophils
Nucleoproteins - genetics
Nucleoproteins - immunology
Pathogenesis
Pathology
Public health
Pulmonary inflammation
Recombinant vaccine
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - immunology
Respiratory Syncytial Virus Infections - prevention & control
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus Vaccines - administration & dosage
Respiratory Syncytial Virus Vaccines - genetics
Respiratory Syncytial Virus Vaccines - immunology
Respiratory Syncytial Virus, Human - drug effects
Respiratory Syncytial Virus, Human - immunology
Respiratory Syncytial Virus, Human - pathogenicity
T cell receptors
T cells
Th1
Th1 Cells - drug effects
Th1 Cells - immunology
Th1 Cells - virology
Th17
Th17 Cells - drug effects
Th17 Cells - immunology
Th17 Cells - virology
Vaccines
Vaccines, Synthetic
Viral infection
Viral Proteins - genetics
Viral Proteins - immunology
Viruses
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creator Céspedes, Pablo F
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Bueno, Susan M
Kalergis, Alexis M
description Highlights • A single dose of 3 × 105 CFUs of rBCG-N-hRSV cGMP elicits T-cell memory against hRSV. • rBCG-N-hRSV cGMP elicits a strong antiviral TH1/TH17 T-cell repertoire. • Vaccination prevents viral pneumonia and CNS-alterations associated with hRSV. • rBCG-N-hRSV cGMP elicits a strong anti-mycobacterial TH1/TH17 T-cell repertoire. • Immunity to hRSV and Mtb antigens develops without observable adverse effects.
doi_str_mv 10.1016/j.vaccine.2016.12.048
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identifier ISSN: 0264-410X
ispartof Vaccine, 2017-02, Vol.35 (5), p.757-766
issn 0264-410X
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language eng
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source ScienceDirect Journals
subjects Allergy and Immunology
Animals
Antigens
Bacillus Calmette et Guerin
BCG Vaccine - administration & dosage
BCG Vaccine - genetics
BCG Vaccine - immunology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - virology
Epidemics
Human health and pathology
Human respiratory syncytial virus
Humans
Immunity, Cellular - drug effects
Immunization
Immunization Schedule
Immunogenicity, Vaccine
Immunology
Infections
Interferon-gamma - biosynthesis
Interferon-gamma - immunology
Interleukin-17 - biosynthesis
Interleukin-17 - immunology
Laboratory animals
Life Sciences
Lung - drug effects
Lung - immunology
Lung - virology
Lungs
Lymphocyte Activation - drug effects
Lymphocytes
Mice
Mice, Inbred BALB C
Neutrophils
Nucleoproteins - genetics
Nucleoproteins - immunology
Pathogenesis
Pathology
Public health
Pulmonary inflammation
Recombinant vaccine
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - immunology
Respiratory Syncytial Virus Infections - prevention & control
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus Vaccines - administration & dosage
Respiratory Syncytial Virus Vaccines - genetics
Respiratory Syncytial Virus Vaccines - immunology
Respiratory Syncytial Virus, Human - drug effects
Respiratory Syncytial Virus, Human - immunology
Respiratory Syncytial Virus, Human - pathogenicity
T cell receptors
T cells
Th1
Th1 Cells - drug effects
Th1 Cells - immunology
Th1 Cells - virology
Th17
Th17 Cells - drug effects
Th17 Cells - immunology
Th17 Cells - virology
Vaccines
Vaccines, Synthetic
Viral infection
Viral Proteins - genetics
Viral Proteins - immunology
Viruses
title A single, low dose of a cGMP recombinant BCG vaccine elicits protective T cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice
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