Focal and diffuse cervical spinal cord damage in patients with early relapsing–remitting MS: A multicentre magnetisation transfer ratio study

Background: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). Objectives: The objectives are to (1) assess whether MTR reduction is already measurable...

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Published in:Multiple sclerosis 2019-07, Vol.25 (8), p.1113-1123
Main Authors: Combès, Benoît, Kerbrat, Anne, Ferré, Jean Christophe, Callot, Virginie, Maranzano, Josefina, Badji, Atef, Le Page, Emmanuelle, Labauge, Pierre, Ayrignac, Xavier, Carra Dallière, Clarisse, de Champfleur, Nicolas Menjot, Pelletier, Jean, Maarouf, Adil, de Seze, Jérôme, Collongues, Nicolas, Brassat, David, Durand-Dubief, Françoise, Barillot, Christian, Bannier, Elise, Edan, Gilles
Format: Article
Language:English
Subjects:
Adult
Cervical Cord - diagnostic imaging
Cervical Cord - pathology
Female
Humans
Life Sciences
Magnetic Resonance Imaging - methods
Male
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - pathology
Neuroimaging
Neurons and Cognition
Spatial distribution
Spinal cord
Vertebrae
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Summary:Background: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). Objectives: The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing–remitting multiple sclerosis (RRMS) and (2) describe its spatial distribution. Methods: We included 60 patients with RRMS
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458518781999