FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways

Upon recognition of nonpeptidic phosphoantigens, human Vδ2 T lymphocytes enter a lineage differentiation pattern that determines the generation of memory cells with a range of effector functions. Here, we show that within the effector memory Vδ2 population, 2 distinct and complementary subsets with...

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Bibliographic Details
Published in:Blood 2004-09, Vol.104 (6), p.1801-1807
Main Authors: Angelini, Daniela F., Borsellino, Giovanna, Poupot, Mary, Diamantini, Adamo, Poupot, Rémy, Bernardi, Giorgio, Poccia, Fabrizio, Fournié, Jean-Jacques, Battistini, Luca
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells, Cultured
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hematology
Human health and pathology
Humans
Immunobiology
Killer Cells, Natural
Life Sciences
Lymphocyte Activation
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
Phenotype
Receptors, Antigen, T-Cell, gamma-delta
Receptors, Chemokine
Receptors, IgG
T-Lymphocyte Subsets
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Summary:Upon recognition of nonpeptidic phosphoantigens, human Vδ2 T lymphocytes enter a lineage differentiation pattern that determines the generation of memory cells with a range of effector functions. Here, we show that within the effector memory Vδ2 population, 2 distinct and complementary subsets with regard to phenotype, mode of activation, and type of responses can be identified: Vδ2 TEMhcells, which express high levels of chemokine receptors, but low levels of perforin and of natural killer receptors (NKRs) and which produce large amounts of interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α) in response to T-cell receptor (TCR)–specific stimulation by phosphoantigens; and Vδ2TEMRAcells, which constitutively express several NKRs, high amounts of perforin, but low levels of chemokine receptors and of IFN-γ. These NK-like cells are refractory to phosphoantigen but respond to activation via FcγRIII (CD16) and are highly active against tumoral target cells. Thus, circulating Vδ2T lymphocytes comprise 2 functionally diverse subsets of effector memory cells that may be discriminated on the basis of CD16 expression.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2004-01-0331