Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity

Background & aims-Hepatitis B virus (HBV) RNA can undergo alternative splicing but the relevance of this post-transcriptional regulation remains elusive. Here, the mechanism of HBV alternative splicing regulation and its impact on liver pathogenesis were investigated. Methods-HBV RNA-interacting...

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Bibliographic Details
Published in:Journal of hepatology 2017-10, Vol.67 (4), p.687-699
Main Authors: Duriez, Marion, Mandouri, Yassmina, Lekbaby, Bouchra, Wang, Hualin, Schnuriger, Aurélie, Redelsperger, Francois, Guerrera, Chiara Ida, Lefevre, Marine, Fauveau, Veronique, Ahodantin, James, Quetier, Ivan, Chhuon, Cerina, Gourari, Samir, Boissonnas, Alexandre, Gill, Upkar, Kennedy, Patrick, Debzi, Nabil, Sitterlin, Delphine, Maini, Mala K, Kremsdorf, Dina, Soussan, Patrick
Format: Article
Language:English
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Life Sciences
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Summary:Background & aims-Hepatitis B virus (HBV) RNA can undergo alternative splicing but the relevance of this post-transcriptional regulation remains elusive. Here, the mechanism of HBV alternative splicing regulation and its impact on liver pathogenesis were investigated. Methods-HBV RNA-interacting proteins were identified by RNA pull-down combined to mass spectrometry analysis. HBV splicing regulation was investigated in chemically and surgically induced liver damage in whole HBV genome transgenic mice and in hepatoma cells. Viral and
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2017.05.025