Cytoplasmic access by intracellular bacterial pathogens

Highlights • Novel technological developments allow tracking of vacuolar rupture and show that more bacterial pathogens contact the host cytoplasm. • Both bacterial and host factors work together to achieve vacuole escape for most vacuole-rupturing pathogens. • Cytosolic contact elicits different ho...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2014-03, Vol.22 (3), p.128-137
Main Authors: Fredlund, Jennifer, Enninga, Jost
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial Physiological Phenomena
Biochemistry
Biochemistry, Molecular Biology
Cell Behavior
Cellular Biology
Cytoplasm - microbiology
Endocytosis
host cell death
Host-Pathogen Interactions
Humans
Internal Medicine
intracellular bacteria
Life Sciences
membrane trafficking
Microbiology and Parasitology
Models, Biological
vacuolar rupture
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Summary:Highlights • Novel technological developments allow tracking of vacuolar rupture and show that more bacterial pathogens contact the host cytoplasm. • Both bacterial and host factors work together to achieve vacuole escape for most vacuole-rupturing pathogens. • Cytosolic contact elicits different host cellular responses, including autophagy and cell death. • Host cell responses to cytoplasmic bacteria have consequences for both the pathogen and the whole organism.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2014.01.003