Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance

BACKGROUND: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.OBJECTIVE: To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance...

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Bibliographic Details
Published in:The international journal of tuberculosis and lung disease 2015-06, Vol.19 (6), p.679-684
Main Authors: Alame-Emane, A. K., Xu, P., Pierre-Audigier, C., Cadet-Daniel, V., Shen, X., Sraouia, M., Siawaya, J. F. Djoba, Takiff, H., Gao, Q., Gicquel, B
Format: Article
Language:English
Subjects:
Amidohydrolases - genetics
Antitubercular Agents - therapeutic use
Biochemistry, Molecular Biology
China - epidemiology
DNA Mutational Analysis
DNA, Bacterial - genetics
Drug Resistance
Drug Resistance, Multiple, Bacterial - genetics
Extensively Drug-Resistant Tuberculosis - diagnosis
Extensively Drug-Resistant Tuberculosis - drug therapy
Extensively Drug-Resistant Tuberculosis - epidemiology
Extensively Drug-Resistant Tuberculosis - microbiology
Fluoroquinolones - therapeutic use
Gene Frequency
Genotype
Humans
Life Sciences
Microbial Sensitivity Tests
Molecular biology
Mutation
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Paris - epidemiology
Pharmaceutical sciences
Pharmacology
Phenotype
Pyrazinamide
Pyrazinamide - therapeutic use
Rifampin - therapeutic use
Tuberculosis
Tuberculosis, Multidrug-Resistant - diagnosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:BACKGROUND: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.OBJECTIVE: To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP).DESIGN: Isolates from two major urban centres-Paris (101 strains) and Shanghai (171 strains)-were investigated for the association of pncA mutations with resistance to drugs other than PZA.RESULTS: The proportion of pncA mutations found in INH-monoresistant strains was not increased.CONCLUSION: pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.14.0768