Adiponectin expression and metabolic markers in obesity and Type 2 diabetes

BACKGROUNDAdiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxis...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endocrinological investigation 2011-02, Vol.34 (2), p.e16-e23
Main Authors: Kouidhi, S, Jarboui, S, Marrakchi, R, Froidevaux, M-S Clerget, Seugnet, I, Abid, H, Bchir, F, Brahem, M, Demeneix, B, Guissouma, H, Elgaaied, A Benammar
Format: Article
Language:English
Subjects:
Endocrinology and metabolism
Human health and pathology
Life Sciences
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUNDAdiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxisome proliferator-activated receptor- γ (PPAR-γ) plays an important, and beneficial, role in modulating adiponectin expression. AIMThe aim of the present study was to assess the separate role of obesity and Type 2 diabetes in the relationship between endogenous PPAR-γ signaling and adiponectin expression in subcutaneous adipose tissue. SUBJECTS AND METHODSEnzyme-linked immuno sor bent assay and real time quantitative PCR analysis were carried out in overweight, obese, and/or diabetic Tunisian patients who underwent an abdominal surgery. RESULTSThese results collectively indicate that circulating levels of adiponectin were decreased in all overweight, obese, and/or diabetic (p
ISSN:0391-4097
1720-8386
DOI:10.3275/7204