Invasive Pulmonary Infection Due to Trichoderma longibrachiatum Mimicking Invasive Aspergillosis in a Neutropenic Patient Successfully Treated with Voriconazole Combined with Caspofungin

Trichoderma longibrachiatum, a filamentous fungus, was recently described as an emerging pathogen in immunocompromised patients. Here, we report the first case, to our knowledge, of isolated invasive lung infection by T. longibrachiatum in a patient with hematologic malignancy. The infection mimicke...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-05, Vol.46 (10), p.e116-e118
Main Authors: Alanio, Alexandre, Brethon, Benoît, de Chauvin, Martine Feuilhade, de Kerviler, Eric, Leblanc, Thierry, Lacroix, Claire, Baruchel, André, Menotti, Jean
Format: Article
Language:English
Subjects:
Adolescent
Antifungal Agents - therapeutic use
Aspergillus
Diagnosis, Differential
Drug Therapy, Combination
Echinocandins - therapeutic use
Hematologic Neoplasms - complications
Humans
Life Sciences
Lipopeptides
Male
Mycoses - diagnosis
Mycoses - drug therapy
Neutropenia - complications
Pneumonia - drug therapy
Pneumonia - microbiology
Pyrimidines - therapeutic use
Radiography, Thoracic
Tomography, X-Ray Computed
Triazoles - therapeutic use
Trichoderma - isolation & purification
Trichoderma longibrachiatum
Voriconazole
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Summary:Trichoderma longibrachiatum, a filamentous fungus, was recently described as an emerging pathogen in immunocompromised patients. Here, we report the first case, to our knowledge, of isolated invasive lung infection by T. longibrachiatum in a patient with hematologic malignancy. The infection mimicked invasive pulmonary aspergillosis and was successfully treated with a combination of voriconazole and caspofungin.
ISSN:1058-4838
1537-6591
DOI:10.1086/587750