Sustained transmission of dengue virus type 1 in the Pacific due to repeated introductions of different Asian strains

Outbreaks of dengue due to dengue virus type 1 (DENV-1) occurred almost simultaneously in 2001 in Myanmar and at multiple sites almost 10,000 km away in the Pacific. Phylogenetic analyses of the E protein genes of DENV-1 strains recovered from Asia and the Pacific revealed three major viral genotype...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2004-11, Vol.329 (2), p.505-512
Main Authors: A-Nuegoonpipat, Atchareeya, Berlioz-Arthaud, Alain, Chow, Vincent, Endy, Tim, Lowry, Kym, Mai, Le Quynh, Ninh, Truong Uyen, Pyke, Alyssa, Reid, Mark, Reynes, Jean-Marc, Su Yun, Se-Thoe, Thu, Hlaing Myat, Wong, Sook-San, Holmes, Edward C., Aaskov, John
Format: Article
Language:English
Subjects:
Animals
Asia
Asia - epidemiology
Asia and the Pacific
Dengue
Dengue - epidemiology
Dengue - transmission
Dengue Virus
Dengue Virus - genetics
Dengue virus type 1
Dengue viruses
Disease Outbreaks
epidemiology
evolution
Fiji
Fiji - epidemiology
Genotype
Human health and pathology
Humans
Infectious diseases
Life Sciences
Microbiology and Parasitology
Molecular Epidemiology
New Caledonia
New Caledonia - epidemiology
Phylogeny
Santé publique et épidémiologie
Viral Envelope Proteins
Viral Envelope Proteins - genetics
Virology
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Summary:Outbreaks of dengue due to dengue virus type 1 (DENV-1) occurred almost simultaneously in 2001 in Myanmar and at multiple sites almost 10,000 km away in the Pacific. Phylogenetic analyses of the E protein genes of DENV-1 strains recovered from Asia and the Pacific revealed three major viral genotypes (I, II, and III) with distinct clades within each. The majority of strains from the Pacific and Myanmar, and a number of other Asian strains fell into genotype I. Genotype II comprised a smaller set of Asian and Pacific strains, while genotype III contained viruses from diverse geographical localities. These analyses suggested that the continuing outbreak of dengue in the Pacific has been due to multiple, direct, introductions of dengue viruses from a variety of locations in Asia followed by local transmission. There was no evidence that the introduction of these viruses into the Pacific was associated with any adaptive changes in the E protein of the viruses.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2004.08.029