The Pro variant of the p53 codon 72 polymorphism is associated with hepatocellular carcinoma in Moroccan population

Aim:  Codon 72 polymorphism of the p53 gene has been implicated in cancer risk, and it has been suggested that it may have an impact on the clinical outcome of the disease. Our objective was to evaluate the association between p53 polymorphism at codon 72 and hepatocellular carcinoma (HCC) in the Mo...

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Bibliographic Details
Published in:Hepatology research 2007-09, Vol.37 (9), p.748-754
Main Authors: Ezzikouri, Sayeh, El feydi, Abdellah Essaid, Chafik, Abdelaziz, Benazzouz, Mustapha, El kihal, Latifa, Afifi, Rajae, Hassar, Mohammed, Pineau, Pascal, Benjelloun, Soumaya
Format: Article
Language:English
Subjects:
Cancer
codon 72 polymorphism
Genetics
Hepatitis C virus
hepatocellular carcinoma
Human genetics
Human health and pathology
Hépatology and Gastroenterology
Life Sciences
Morocco
p53
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Summary:Aim:  Codon 72 polymorphism of the p53 gene has been implicated in cancer risk, and it has been suggested that it may have an impact on the clinical outcome of the disease. Our objective was to evaluate the association between p53 polymorphism at codon 72 and hepatocellular carcinoma (HCC) in the Moroccan population. Methods:  Genomic DNA was extracted from peripheral blood cells of 96 patients with HCC and 222 controls without HCC matched for age, gender and ethnicity. Codon 72 polymorphism of p53 was identified by PCR‐restriction fragment length polymorphism, confirmed by sequencing. Results:  Patients with HCC had higher frequencies of Pro/Pro (13.5% vs. 6.3%, P 
ISSN:1386-6346
1872-034X
DOI:10.1111/j.1872-034X.2007.00126.x