Distinguishing features of developing natural killer cells

Although NK cells were initially described as lymphocytes that lacked the characteristic markers of B and T cells, we now appreciate the plethora of activating and inhibitory receptors that define the NK cell surface phenotype. Recent studies have provided new insights into the molecular mechanisms...

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Bibliographic Details
Published in:Current opinion in immunology 2005-04, Vol.17 (2), p.151-158
Main Authors: Vosshenrich, Christian AJ, Samson-Villéger, Sandrine I, Di Santo, James P
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cell Differentiation - genetics
Cell Differentiation - immunology
Cell Differentiation - physiology
Cytokines
Cytokines - physiology
Homeostasis
Homeostasis - physiology
Humans
Immune System
Immune System - immunology
Immune System - physiology
Killer Cells, Natural
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Killer Cells, Natural - physiology
Life Sciences
Lymphocyte Activation
Lymphocyte Activation - physiology
Transcription Factors
Transcription Factors - physiology
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Summary:Although NK cells were initially described as lymphocytes that lacked the characteristic markers of B and T cells, we now appreciate the plethora of activating and inhibitory receptors that define the NK cell surface phenotype. Recent studies have provided new insights into the molecular mechanisms that drive NK cell development, control the NK cell receptor repertoire and the cytokines that define the NK cell niche. These findings form the basis for an updated model of NK cell differentiation.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2005.01.005