Serological and Molecular Evidence That Human Herpesvirus 8 Is Endemic among Amerindians in French Guiana

We evaluated the presence of human herpesvirus 8 (HHV‐8) infection among groups of Amerindians in French Guiana. The overall prevalence of antibodies against lytic HHV‐8 antigens was 23.0% (180/781), increasing from 18.4% in children 45 years). Seroprevalence was higher in Amerindians living in remo...

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Bibliographic Details
Published in:The Journal of infectious diseases 2005-11, Vol.192 (9), p.1525-1529
Main Authors: Kazanji, Mirdad , Dussart, Philippe , Duprez, Renan , Tortevoye, Patricia , Pouliquen, Jean‐François , Vandekerkhove, Julie , Couppié, Pierre , Morvan, Jacques , Talarmin, Antoine , Gessain, Antoine 
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies
Antibodies, Viral
Antibodies, Viral - blood
Basic-Leucine Zipper Transcription Factors
Basic-Leucine Zipper Transcription Factors - immunology
Biological and medical sciences
Child
Child, Preschool
DNA, Viral
DNA, Viral - genetics
Endemic Diseases
Ethnic groups
French Guiana
French Guiana - epidemiology
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genotypes
Herpesviridae
Herpesviridae Infections
Herpesviridae Infections - blood
Herpesviridae Infections - epidemiology
Herpesviridae Infections - ethnology
Herpesviridae Infections - virology
Herpesvirus 8, Human
Herpesvirus 8, Human - classification
Herpesvirus 8, Human - genetics
Herpesvirus 8, Human - isolation & purification
Human herpesvirus 8
Humans
Indians, North American
Infant
Infections
Infectious diseases
Life Sciences
Medical sciences
Microbiology
Microbiology and Parasitology
Middle Aged
Miscellaneous
Parametric models
Phylogenetics
Prevalence
Repressor Proteins
Repressor Proteins - immunology
Rural Population
Seroepidemiologic Studies
Viral Proteins
Viral Proteins - genetics
Viral Proteins - immunology
Virology
Viruses
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Summary:We evaluated the presence of human herpesvirus 8 (HHV‐8) infection among groups of Amerindians in French Guiana. The overall prevalence of antibodies against lytic HHV‐8 antigens was 23.0% (180/781), increasing from 18.4% in children 45 years). Seroprevalence was higher in Amerindians living in remote localities than it was in those living in the coastal region. Analysis of a 725–base pair fragment of the K1 gene amplified from DNA from a Wayampi Amerindian showed that the virus belonged to molecular subtype E, which has hitherto been found in only a few Amerindians in Brazil and Ecuador.
ISSN:0022-1899
1537-6613
DOI:10.1086/491744