Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats

• Published in: Infection, genetics and evolution genetics and evolution, 2021-09, Vol.93, p.104916, Article 104916
• Main Authors: de Thoisy, Benoît, Duron, Olivier, Epelboin, Loïc, Musset, Lise, Quénel, Philippe, Roche, Benjamin, Binetruy, Florian, Briolant, Sébastien, Carvalho, Luisiane, Chavy, Agathe, Couppié, Pierre, Demar, Magalie, Douine, Maylis, Dusfour, Isabelle, Epelboin, Yanouk, Flamand, Claude, Franc, Alain, Ginouvès, Marine, Gourbière, Sébastien, Houël, Emeline, Kocher, Arthur, Lavergne, Anne, Le Turnier, Paul, Mathieu, Luana, Murienne, Jérôme, Nacher, Mathieu, Pelleau, Stéphane, Prévot, Ghislaine, Rousset, Dominique, Roux, Emmanuel, Schaub, Roxane, Talaga, Stanislas, Thill, Pauline, Tirera, Sourakhata, Guégan, Jean-François
• Format: Article
• Language: English
• Subjects: Animals; Animals, Wild; Anthropogenic pressures; Demography; Ecosystem; Emerging and reemerging infectious diseases; Emerging diseases; Environmental Sciences; Epidemiologic transition; French Guiana; French Guiana - epidemiology; Global change; Global Changes; Human Activities; Human health and pathology; Humans; Incidence; Infectious diseases; Interdisciplinary Research; Life Sciences; Prevalence; Vector Borne Diseases - epidemiology; Vector Borne Diseases - transmission; Zoonoses - epidemiology; Zoonoses - etiology; Zoonoses - transmission
• ISSN: 1567-1348; 1567-7257
• DOI: 10.1016/j.meegid.2021.104916

French Guiana is a European ultraperipheric region located on the northern Atlantic coast of South America. It constitutes an important forested region for biological conservation in the Neotropics. Although very sparsely populated, with its inhabitants mainly concentrated on the Atlantic coastal strip and along the two main rivers, it is marked by the presence and development of old and new epidemic disease outbreaks, both research and health priorities. In this review paper, we synthetize 15 years of multidisciplinary and integrative research at the interface between wildlife, ecosystem modification, human activities and sociodemographic development, and human health. This study reveals a complex epidemiological landscape marked by important transitional changes, facilitated by increased interconnections between wildlife, land-use change and human occupation and activity, human and trade transportation, demography with substantial immigration, and identified vector and parasite pharmacological resistance. Among other French Guianese characteristics, we demonstrate herein the existence of more complex multi-host disease life cycles than previously described for several disease systems in Central and South America, which clearly indicates that today the greater promiscuity between wildlife and humans due to demographic and economic pressures may offer novel settings for microbes and their hosts to circulate and spread. French Guiana is a microcosm that crystallizes all the current global environmental, demographic and socioeconomic change conditions, which may favor the development of ancient and future infectious diseases. •Both scientific and biomedical research tends to work in silos, what the OneHealth and Ecohealth concepts keep hammering.•Zoonotic and vector-borne (ZVBID) infectious diseases form an important group of diseases emerging and reemerging worldwide.•15 years of research in French Guiana (South America) on ZVBID reveals new insights onto the wildlife-ecosystem-disease nexus.•Environmental, demographic, socioeconomic changes in French Guiana favor the development of ancient and new ZVBID.